Effect of Beta Blocker Treatment on Endothelial Function in Patients With Type 2 Diabetes or Chronic Heart Failure
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Endothelial function and insulin stimulated endothelial function
研究概览
简要总结
The aim of this study is to evaluate the effect of the two different beta blockers metoprolol and carvedilol on endothelial function in patients with either type two diabetes or chronic heart failure.
Hypothesis: 1* Carvedilol compared to metoprolol has a favourable effect on endothelial function.
2* Carvedilol compared to metoprolol has a favourable effect on insulin stimulated endothelial function.
The study is conducted as an open parallel group study. Endothelial function and insulin stimulated endothelial function was evaluated before and after a two months treatment period with either of the two beta blockers.
详细描述
Endothelial function is deteriorated in patients with type 2 diabetes and in patients with chronic heart failure. Treatment with carvedilol improves survival in patients with chronic heart failure compared to treatment with metoprolol. Carvedilol improves metabolic glucose control in patients with diabetes compared to metoprolol.Carvedilol compared to metoprolol also decreases the number of patients with new onset diabetes among patients with chronic heart failure. The mechanism behind these findings has not been fully understood.
The purpose of this study is to investigate if carvedilol compared to metoprolol has a favourable effect on endothelial function and insulin stimulated endothelial function, in groups of patients with either diabetes or chronic heart failure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Type 2 diabetes
- •Chronic heart failure
排除标准
- •For patients with type 2 diabetes:
- •* Vascular complications.
- •For patients with chronic heart failure:
- •Severe uncontrolled heart failure.
- •Untreated severe hypertension, hypotension.
- •Bradycardia.
- •Known intolerance to beta blocker treatment.
- •Pregnancy,
结局指标
主要结局
Endothelial function and insulin stimulated endothelial function
时间窗: 2 months
次要结局
- Insulin stimulated glucose uptake(2 months)