Pilot Study Of T-Cell-Depleted Peripheral Blood Stem Cell Transplantation From Partially Matched Related Donors For Patients With High-Risk Leukemia
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 51
- 试验地点
- 2
- 主要终点
- Incidence of acute and chronic graft-vs-host disease100 days post-transplant
研究概览
简要总结
RATIONALE: Giving chemotherapy and total-body irradiation before a donor peripheral stem cell transplant helps stop the growth of cancer and abnormal cells and helps stop the patient's immune system from rejecting the donor's stem cells. When the stem cells from a related donor, that do not exactly match the patient's blood, are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets.
PURPOSE: This phase II trial is studying how well peripheral stem cell transplant works in treating patients with high-risk leukemia.
详细描述
OBJECTIVES:
- Determine the safety of a preparative regimen comprising total body irradiation, cyclophosphamide, thiotepa, and fludarabine, but without anti-thymocyte globulin, in patients with high-risk leukemia treated with peripheral blood stem cell transplantation from partially matched related donors.
- Determine the incidence of graft failure, acute graft-versus-host disease (GVHD), and treatment-related mortality in patients treated with this regimen.
- Determine rates of chronic GVHD and relapse in patients treated with this regimen.
- Determine disease-free and overall survival in patients treated with this regimen.
OUTLINE: This is a pilot study.
Patients receive a preparative regimen comprising total lymphoid irradiation once daily on days -13 to -11; cyclophosphamide IV over 1 hour on days -8 and -7; thiotepa IV over 4 hours every 12 hours on day -6; fludarabine IV over 30 minutes on days -5 to -1; and total body irradiation once on day -1. Patients also receive cyclosporine IV over 12 hours on days -8 to -1 and methylprednisolone IV twice daily on days -3 and -2. Patients receive CD34-enriched T-cell-depleted allogeneic stem cell infusion on day 0.
Patients with disease progression or uncontrolled infection but without grade II or greater graft-versus-host disease may receive up to 3 donor lymphocyte infusions at least 4 weeks apart until disease regression.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 10 Years 至 50 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DISEASE CHARACTERISTICS:
- •Diagnosis of 1 of the following:
- •High-risk myelodysplastic syndromes (MDS), meeting 1 of the following criteria:
- •Transformation to acute leukemia defined by at least 15% blasts
- •Secondary to prior treatment with chemotherapy and/or radiotherapy
- •Presence of complex cytogenetics (at least 3 karyotypic abnormalities)
- •Monosomy or deletion of chromosome 7
- •Acute myeloid leukemia (AML), meeting 1 of the following criteria :
- •High-risk AML in first remission and meeting 1 of the following criteria:
- •At least 3 karyotypic abnormalities
- •Monosomy or deletion of chromosome 5 or 7 = 11q23 chromosomal abnormality
- •Prior diagnosis of MDS
- •Received prior radiotherapy or chemotherapy
- •In second or subsequent remission
- •Primary induction failure or partial remission
- •Untested or sensitive relapse
- •Chronic myelogenous leukemia, meeting 1 of the following criteria:
- •Blast crisis
- •Accelerated phase disease that has failed prior treatment with imatinib mesylate, defined as a failure to achieve hematologic response after 3 months of standard dose (600 mg/day) therapy or disease progression on therapy
- •Myeloproliferative disease
- •The following diagnoses are eligible:
- •Agnogenic myeloid metaplasia
- •Essential thrombocythemia
- •Polycythemia vera
- •Must have evidence of transformation to acute leukemia
- •Acute lymphocytic leukemia (ALL), meeting 1 of the following criteria:
- •High-risk ALL in first remission defined by 1 of the following:
- •t(9;22) or 11q23 chromosomal abnormality
- •Complete response at least 4 weeks after induction therapy OR requiring at least 2 induction regimens
- •Second or subsequent remission
- •No relapsed leukemia refractory to appropriate salvage therapy
- •Availability of an HLA-mismatched family donor
- •Donor age 75 or under
- •No better donor alternative (i.e., HLA-matched related or unrelated stem cell donor) is available
- •PATIENT CHARACTERISTICS:
- •Performance status
- •Life expectancy
- •More than 3 months
- •Hematopoietic
- •See Disease Characteristics
- •Bilirubin no greater than 4 mg/dL
- •Transaminases no greater than 3 times upper limit of normal
- •Creatinine no greater than 2.0 mg/dL OR
- •Creatinine clearance at least 60 mL/min
- •Cardiovascular
- •LVEF at least 40%
- •DLCO at least 65% of predicted
- •Not pregnant
- •Negative pregnancy test
- •HIV negative
- 另有 15 项未显示
排除标准
- 未提供
结局指标
主要结局
Incidence of acute and chronic graft-vs-host disease100 days post-transplant
Transplant-related mortality 100 days post-transplant
Disease-free survival 100 days post-transplant
Overall survival 100 days post-transplant
Incidence of graft failure 100 days post-transplant
次要结局
未报告次要终点