Visuocortical Dynamics of Affect-Biased Attention in the Development of Adolescent Depression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Affect-biased Attention Following Neurofeedback (Immediately Post-Intervention)
研究概览
简要总结
Rates of depression increase rapidly during adolescence, especially for girls, and, thus, research is needed to spur the development of novel interventions to prevent adolescent depression. This project seeks to determine if a novel visuocortical probe of affect-biased attention (i.e., steady-state visual evoked potentials derived from EEG) can 1) be used to prospectively predict depression using a multi-wave repeated measures design and 2) modify affect-biased attention and buffer subsequent mood reactivity using real time neurofeedback. This work could ultimately lead to improved identification of adolescents who are at high risk for depression and directly inform the development of mechanistic treatment targets to be used in personalized intervention prescriptions for high-risk youth.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 13 Years 至 15 Years（Child）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Participants will include 90 female adolescents ages 13 years 0 months through 15 years 11 months at study entry.
排除标准
- •Lifetime history of any Diagnostic and Statistical Manual of Mental Disorders (DSM) 5 depressive disorder
- •Lifetime history of taking antidepressants [e.g., selective serotonin reuptake inhibitor (SSRIs)]
- •Lifetime history of a DSM 5 psychotic, bipolar, or autistic spectrum disorder.
- •Presence of EEG contraindications (e.g., personal lifetime history of seizures or family history of hereditary epilepsy).
- •Being pre-pubertal
- •Lifetime history of a neurological or serious medical condition.
- •Lifetime history of head injury or congenital neurological anomalies (based on parent report).
- •Intelligence quotient (IQ) less than 80, as assessed using the Wechsler Abbreviated Scale of Intelligence (WASI).
- •Uncorrected visual disturbance
- •Being acutely suicidal or at risk for harm to self or others.
结局指标
主要结局
Affect-biased Attention Following Neurofeedback (Immediately Post-Intervention)
时间窗: Approximately 1 hour total: baseline assessment immediately before neurofeedback and post-neurofeedback assessment immediately after the ~1 hour training session on the same day.
To measure affect-biased attention, steady-state visual evoked potentials (SSVEPs) were derived from EEG and used to index the amount of stimulus-driven attention to negative distractors relative to task-relevant stimuli. Affect-biased attention was assessed immediately before and immediately after the real-time SSVEP neurofeedback training to evaluate changes within the same session. The outcome below reflects the post-neurofeedback SSVEP competition index (Task / \[Task + Distractor\]). Scores above .50 indicate greater attention to the task stimulus.
次要结局
- Sadness Ratings Following Laboratory Stressor (Immediately Post-Stressor)(Approximately 30 minutes total: baseline sadness rating immediately before and post-stressor rating immediately after the ~30-minute laboratory stressor on the same day.)
- Anxiety Rating Following Laboratory Stressor (Immediately Post-Stressor)(Baseline and following laboratory stressor (~30 minutes))
研究者
Mary Woody
Assistant Professor
University of Pittsburgh