International Prospective Observational Cohort Study for Optimal Bowel Resection Extent and Central Radicality for Colon Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 3,647
- 试验地点
- 36
- 主要终点
- Distribution of metastatic LNs
研究概览
简要总结
The T-REX study aims to clarify the actual status of metastatic lymph node (LN) distribution in colon cancer and provide reliable evidence regarding the optimal length of bowel resection and the extent of central lymph node dissection in colon cancer surgery.
详细描述
In colon canser, the incidence of metastasis in the pericolic lymph nodes (LNs) located along the bowel and marginal artery is high. The optimal extent of bowel resection is closely associated with how we define 'regional' pericolic LNs, which should be resected because of the risk of metastasis. However, there are no standardised criteria for 'regional' LNs in the pericolic area.
To establish a consensus for the extent of bowel resection and appropriate central LN dissection, international prospective stdies focusing on the distribution of metastatic LNs along the bowel and the primary feeding artery are conducted.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically proven colon adenocarcinoma
- •Pathological stage Ⅰ, Ⅱ or Ⅲ
- •Potentially curative surgery
- •Informed consent for observational data collection
排除标准
- •Tis (mucosal cancer)
- •Multiple colon cancers
- •All patients with preoperative adjuvant therapy
结局指标
主要结局
Distribution of metastatic LNs
时间窗: At the time of 4 years after surgery
Distribution of metastatic LNs
时间窗: At the time of patient registry in
次要结局
- Prognostic outcomes according to the length of bowel resection(4 years)
- Prognostic outcomes according to the central radicality(4 years)