JPRN-UMIN000025579未知2 期
An exploratory phase II study of neoadjuvant bevacizumab and temozolomide chemotherapy for patients with newly diagnosed malignant glioma - Neoadjuvant bevacizumab and temozolomide for malignant glioma
适应症
试验速览
- 阶段
- 2 期
- 入组人数
- 15
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18years-old 至 75years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1) Uncontrollable severe infectious diseases. 2) Presence of active other cancers. 3) History of radiotherapy for head 4) Uncontrollable hypertention: SAP>150mmHg, DBP>100mmHg 5) Clinically significant cardiac disease (ex. congestive heart failure:NYHA gradeII) 6) Symptomatic myocardial infarction, cerebral infarction, deep vein thrombosis and pulmonary embolism within 6 months 7) Symptomatic intracerebral hemorrhage within 6 months 8) Hemoptysis within 28 days (CTCAE v4.0: grade2) 9) Bleeding diathesis and blood coagulation disorder 10) Unhealed scar and untreated bone fracture 11) Severe gastric ulcer 12) Pulmonary fibrosis and interstitial pneumonia 13) Pregnancy or lactation. Patients hope pregnancy 14) Allergy for temozolomide or bevacizumab 15) Allergy for gadolinium 16) Judged as inappropriate for this study by doctors.
研究者
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