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临床试验/NCT07730216
NCT07730216招募中不适用

Ultrasonographic Predictors of Adductor Canal Block Effectiveness in Total Knee Arthroplasty

Konya City Hospital1 个研究点 分布在 1 个国家目标入组 623 人开始时间: 2026年8月9日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
623
试验地点
1
主要终点
ACB Failure

研究概览

简要总结

Total knee arthroplasty (TKA) is associated with substantial postoperative pain and opioid requirements, making effective multimodal analgesia essential for early mobilization, functional recovery, and reduction of opioid-related adverse events [1,2]. Adductor canal block (ACB) has become a key component of enhanced recovery after surgery (ERAS) protocols because it provides effective anterior knee analgesia while largely preserving quadriceps muscle strength [2-4]. However, analgesic efficacy after ACB remains variable, and some patients require rescue opioid analgesia despite technically successful block placement [5]. Although ultrasound guidance improves block accuracy, factors such as tissue depth, anatomical variations, saphenous nerve visibility, and injectate spread pattern may influence clinical outcomes [6,7]. Prospective evidence regarding the predictive value of these ultrasound-derived parameters for ACB analgesic failure remains limited. Therefore, this study aims to evaluate whether preoperative ultrasound-derived tissue and target parameters-including skin-to-target depth, subcutaneous fat thickness, muscle thickness, saphenous nerve visibility, and injectate spread pattern-can predict ACB analgesic failure and early postoperative analgesic outcomes following TKA.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Age ≥18 years
  • •Scheduled for elective primary unilateral total knee arthroplasty under spinal anesthesia
  • •American Society of Anesthesiologists (ASA) physical status I-III

排除标准

  • •Daily opioid use or chronic pain syndrome
  • •Diabetic or other clinically diagnosed peripheral neuropathy
  • •Coagulopathy
  • •Infection at the injection site
  • •Known allergy or hypersensitivity to local anesthetics
  • •Revision total knee arthroplasty
  • •Conversion from spinal anesthesia to general anesthesia during surgery
  • •General anesthesia as the planned anesthetic technique

结局指标

主要结局

ACB Failure

时间窗: 0-24 hours

ACB analgesic failure will be defined as the requirement for rescue analgesia during the first 24 hours after block administration, with intravenous tramadol (1 mg/kg) administered to patients with an NRS pain score ≥4.

次要结局

  • Secondary outcome(0-24 hour)
  • Tramadol Consumption(0-24 Hours)

研究者

发起方
Konya City Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Ömer Keklicek

principal investigator

Konya City Hospital

研究点 (1)

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