试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- Mayo Clinic
- 主要终点
- Document brain activation networks with ANT stimulation
研究概览
简要总结
The purpose of this study is to use functional imaging to study the mechanisms of the anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS).
详细描述
Researchers are testing how changing the settings on deep brain stimulation device (DBS) can help reduce the number and severity of seizures. Functional imaging will be used to study the mechanisms of ANT DBS to optimize the device settings to improve the degree of seizure reduction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who have previously undergone anterior thalamic nucleus deep brain stimulation (DBS) for refractory epilepsy.
排除标准
- •Contraindication to MRI; prior brain resective surgery or large area of brain tissue loss (e.g., large area infarction).
研究组 & 干预措施
Anterior Nucleus of the Thalamus (ANT) Deep Brain Stimulation (DBS)
Subjects that have undergone DBS placement for treatment of refractory epilepsy will undergo a fMRI scan. During the fMRI, the subject will undergo alternating short periods of their DBS in the "on" and "off" state with high- and low frequency settings to measure the brain activation changes induced by the DBS.
干预措施: Functional magnetic resonance imaging (fMRI) (Diagnostic Test)
结局指标
主要结局
Document brain activation networks with ANT stimulation
时间窗: Results would be available immediately following processing of the imaging data after each scan
Use resting state fMRI to map brain network activation with high and low frequency of ANT stimulation.
次要结局
未报告次要终点
研究者
Steven A. Messina
Principal Investigator
Mayo Clinic