The Effect of NB-UVB on Interleukin-36 Levels in Psoriasis Lesional Skin
试验速览
- 阶段
- 不适用
- 入组人数
- 25
- 主要终点
- changes in Il-36 levels in 25 psoriasis patients after 26 sessions of NB-UVB
研究概览
简要总结
Psoriasis is an immune-mediated skin disease that affects 1-2 % of the population. Several cytokines have been found to be involved in the complex pathogenesis of this disease. Il- 36 is one of the cytokines sharing in psoriasis pathogenesis, as its levels are elevated in psoriatic plaques. Cathepsin G is known to activate Il- 36 and promote inflammation in psoriasis.NB-UVB is one of the important treatment modalities for psoriasis.
The aim of this study is to detect the effect of NB-UVB on the lesional levels of IL-36 in psoriasis.
详细描述
25 psoriasis patients will receive 26 sessions of phototherapy (NB-UVB). Patients will receive 3 sessions per week. Tissue levels of IL-36 and Cathepsin G will be assessed in skin lesions before starting treatment and after completing the 26 sessions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with psoriasis vulgaris of both sexes
- •Age between 18 and 60 years old.
排除标准
- •Pregnant females
- •Patients receiving systemic treatment or topical treatment for psoriasis within the past two months.
- •Patients having other dermatological diseases.
研究组 & 干预措施
nb-uvb
psoriasis patients will receive 26 sessions of nb-uvb phototherapy
干预措施: NB-UVB (Device)
结局指标
主要结局
changes in Il-36 levels in 25 psoriasis patients after 26 sessions of NB-UVB
时间窗: 6 months
primary
次要结局
- changes in cathepsin G levels in 25 psoriasis patients after 26 sessions of NB-UVB psoriasis(6 months)