Impact of Growth Hormone on Serum N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) and on Cardiac Function and Morphology Evaluated by Magnetic Resonance Imaging in Growth Hormone Deficiency and Acromegaly
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 主要终点
- Changes in cardiac function i relation to changes in the activity of the GH-axis
研究概览
简要总结
To test the hypothesis that both lack and excess of growth hormone (GH) is associated with cardiac abnormalities. Cardiac function and morphology will be evaluated by MRI before and after treatment.
详细描述
It is an open prospective noninterventional clinical study. Treatment and follow-up will be according to usual guidelines, and will be unaffected by inclusion in the study. GHD patients will be treated with daily subcutaneous GH injections. Patients with acromegaly will be treated with either transsphenoidal surgery or by medical treatment with long acting somatostatin analogues, dopamine agonist, GH antagonist or combinations of these treatment modalities.
Patients will be examined by Cardiac MRI before treatment and after one year of treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Peak GH below 6.0 ng/mL during Pyridostigmine-GHRH test.
- •Nadir GH above 0.4 ng/mL and elevated levels of IGF-I during oral glucose tolerance test
排除标准
- •Contraindications for magnetic resonance scan
结局指标
主要结局
Changes in cardiac function i relation to changes in the activity of the GH-axis
次要结局
未报告次要终点