Socioeconomic Determinants of the Chemical Exposome and Its Genotoxic Effects in Children
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 149
- 试验地点
- 2
- 主要终点
- Describe DNA damage
研究概览
简要总结
PESTIFOL will include children over 8 and under 12 years old of different socioeconomic positions (SEP), mostly living in the region of Pays de la Loire. This approach should enable us to assess the impact of the SEP, and therefore social inequalities, on chemical expositions and DNA damage, and to characterize which (classes/mixture of) pollutants are major source of DNA damage. The study will also address potential effects associated with geographical location on the exposome and its biological consequences.
详细描述
Growing evidence points to a complex influence of the exposome on health outcomes. Epidemiological studies show associations between pesticides and cognitive delay and cancers. Only few were conducted in children. Chemical exposures differ between socioeconomic groups. The more disadvantaged the group, the higher are some exposures. However, the effect of the exposome on health is complicated to assess due to the long latencies of most diseases. It is therefore important to link social and chemical exposures to 'immediate' outcomes or molecular risk factors for human diseases. There is a strong connection between DNA damage and chronic diseases such as cancers. However, it is difficult to attribute these risks to specific impregnations.
The present study will address the impact of socioeconomic position, hence social inequalities, on environmental exposures and their biological consequences in children. Our approach is to detect DNA damage in hair follicles and associate these measurements with pesticide detections in the hair matrix and socioeconomic position (SEP).
PESTIFOL will include children over 8 and under 12 years old of different socioeconomic positions (SEP), mostly living in the region of Pays de la Loire. This approach should enable us to assess the impact of the SEP, and therefore social inequalities, on chemical expositions and DNA damage, and to characterize which (classes/mixture of) pollutants are major source of DNA damage. The study will also address potential effects associated with geographical location on the exposome and its biological consequences.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 8 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Children over 8 and under 12 years old at the time of inclusion
- •Children in school in class level CE2, CM1 or CM2
- •Living in the Pays de La Loire region, at least 80% of the time
- •Written informed assent and consent obtained from the participant and both parents or legal representative prior to performing any protocol-related procedures.
排除标准
- •- Disorder precluding understanding of trial information or informed assent.
研究组 & 干预措施
study procedures
Hair cut for DNA damage and chemical exposome variation analysis and Socio-economic characteristics
干预措施: Hair cut (Other)
study procedures
Hair cut for DNA damage and chemical exposome variation analysis and Socio-economic characteristics
干预措施: Socio-economic questionnaires (Other)
结局指标
主要结局
Describe DNA damage
时间窗: 4-6 months
Hair locks and hair follicles will be collected and will be analysed to evaluate the DNA damage : average amount of DNA break foci per nucleus cross-section
Describe socio-economic characteristics.
时间窗: 4-6 months
The socio-economic characteristics will evaluated via parent's questionnaires : parents occupation and education level
次要结局
- Characterize socio-economic indicators(4-6 months)
- Describe DNA damage(4-6 months)
- Characterize chemical exposome variations(4-6 months)
- Characterize socio-economic indicators, geographical area, seasons(4-6 months)