A double-blind, randomized, placebo-controlled trial of individualized homeopathic medicines to treat migraine in adults utilizing Boenninghausen’s hexameter for using Boenninghausen’s Characteristics and Repertory by C.M. Boger

Migraine episodes last 4-72 hours, often with moderate to severe one-sided, pulsating headaches, worsened by physical activity, and accompanied by phonophobia, photophobia, nausea, or vomiting. Global migraine prevalence has risen significantly over the past three decades, from 721.9 million in 1990 to 1.1 billion in 2019, and is now the second leading cause of neurological disability-adjusted life-years. Homeopathy is frequently used therapy to treat migraine , however the research evidence is limited. . The systematic approach to analysis, evaluation, and totality framing using Boenninghausen’s Characteristics and Repertory (BCR) is not clearly outlined in the available literature. Within the chapter choosing the remedy, Dr Boger “shows how the final differentiation depends upon the individualistic or peculiar symptoms. A truly scientific procedure”. He outlines seven key points for remedy selection, which are also explained in Boenninghausen’s Lesser Writings under the hexameter. In this study, these hexameter points will consistently be used to frame totality during repertorization for all cases treated with BCR. This 3 months, double-blind, randomized, placebo-controlled is aimed at evaluating the efficacy of homeopathic medicines in the treatment of migraine in 99 adults. The primary outcome measure is MIDAS, measured at baseline and after 3rd month; the secondary outcomes are SF-36, MYMOP-2 questionnaires, all measured at baseline, and every month, up to 3 months. Comparative analysis will be measured to detect group differences. Results will be published in scientific journals.