NL-OMON20884招募中不适用
Comparison of the effectiveness and tolerability of different doses of intravenous glucocorticoid for the treatment of moderately severe Graves' ophthalmopathy. EUGOGO study C
Prof. dr. W.M. WiersingaDept. of Endocrinology and MetabolismAcademic Medical CenterMeibergdreef 91105 AZ AmsterdamT: +31 20 566 6071F: +31 20 691 7682e-mail: w.m.wiersinga@amc.uva.nl0 个研究点目标入组 159 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 159
研究概览
简要总结
/A
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1. Graves' hyperthyroidism, euthyroid for at least two months by antithyroid drugs or surgery (at least 6 months if I131 is used;
- •2. Moderately severe Graves' ophthalmopathy defined as having at least one of the following signs:
- •a. class 2b-c
- •b. mono-ocular duction <30 degrees
- •c. diplopia Gorman score grade a-c;
- •3. Active Graves' ophthalmopathy (CAS 3 or higher out of 7);
- •4. No past treatment of the ophthalmopathy except for local measures;
- •5. Age 18-70 years.
排除标准
- •1. CAS <3;
- •2. Clinically relevant optic nerve involvement;
- •3. General contra-indications to glucocorticoid infusions;
- •4. Pregnancy;
- •5. No informed consent;
- •6. Viral hepatitis;
- •7. Liver enzymes increased by a factor 2.
研究者
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