Iron Supplementation in Schistosomiasis and Soil Transmitted Helminths Control Programmes in Zambia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 480
- 试验地点
- 1
- 主要终点
- Urine samples examined for schistsoma haematobium at month 0, 3. 6 and 9
研究概览
简要总结
The objectives of this study is:
- to establish the coverage rate of weekly iron supplementation in children in intervention schools over a period of nine months
- document any side effects of weeekly iron supplementation among children in intervention schools over a period of nine months asses the feasibility of incorporating the weekly iron supplementation programme into the normal school activity in intervention schools determine the extent of acceptability and support for the iron supplementation programme by staff at the health centre nearest to the intervention schools
- compare the praziquantel efficacy and schistosomiasis reinfection in children in intervention schools with that of children in control schools following the introduction of weekely iron supplementation over a period of nine months
- determine the impact of weekly iron supplementation on haemoglobin levels of children in intervention schools and compare with children in control schools over a period of nine months
详细描述
Iron deficiency anaemia is a common denominator for both schistosomiasis and soil transmitted helminths. Iron deficiency appears to affect the immune response against schistosomes and intestinal helminths. It therefore follows that correcting the iron deficiency anaemia will improve the efficacy of anthelminthics such as praziquantel (against schistosomiasis) and albendazol (against soil transmitted helminths) and ability of the host immune system to resist reinfection with schistosomes and soil transmitted helminths.
The aim of this study is to identify factors necessary for a successful weekly iron supplementation programme in schistosomiasis and soil transmitted helminths control programmes. In addition impact of weekly iron supplementation programme n haemoglobin levels, efficacy of praziquantel, and schistosomiasis re-infection will be studied.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 9 Years 至 15 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •all schoolchildren, in grade 2 and 3, at four selected schools -
排除标准
- 未提供
结局指标
主要结局
Urine samples examined for schistsoma haematobium at month 0, 3. 6 and 9
Blood samples examined for haemoglobin level mont 0 and month 9
Stool samples examined for schistsoma mansoni at mont 0, 3, 6 and 9
次要结局
- - headache
- nausea
- others
- diarrhoea
- abdominal pain
- Any side effects to iron supplementation, measured every week for the first foru weeks after treatment start. Mesured on:
- vomiting
- body weakness