Strength Training Augmenting Rehabilitation - 1
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Changes in lean mass
研究概览
简要总结
This project aims to determine whether a novel strength training rehabilitation protocol can diminish the negative consequences of limb immobilization and expedite the restoration of muscle function during retraining in healthy individuals.
详细描述
The present study will examine the time course of muscle strength and size adaptations in two groups of volunteers during immobilization and retraining. Both groups will undergo temporary muscle disuse by wearing a shoulder sling and swathe on their non-dominant arm for ~≥10 hours/day for four weeks. One group (immobilization + unilateral training) will perform progressive unilateral strength training of the free limb throughout the immobilization period. The other group (immobilization control) will not undergo any training during the immobilization period. Following immobilization, both groups will undergo four weeks of bilateral strength training to retrain the immobilized arm.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •a body mass index between 18 - 35 kg/m2
- •18-35 years of age
- •right-hand dominant
- •willingness to comply with the immobilization requirements
- •willingness to refrain from strength training outside of the study
- •willingness to comply with the strength training procedures of the study
排除标准
- •a personal or family history of blood clots
- •a personal or family history of thyroid disorders
- •previous orthopedic surgeries to the upper limbs and/or joint pain of the upper limbs in the last 6 months
- •neuromuscular or metabolic disorders
- •osteoarthritis
- •use of hormone replacement therapy (ie., testosterone, estrogen, and/or growth hormone pharmaceuticals)
- •pregnancy and/or nursing
研究组 & 干预措施
Immobilization control
The immobilization control group will undergo arm immobilization. Immobilization will be implemented with four weeks of muscle unloading with a sling and swathe on the nondominant arm. The sling will suspend the arm at the elbow joint with the elbow in a flexed position at 90°, the swathe will then wrap around the participant to fix the arm against the body.
干预措施: Orthopedic immobilization (Procedure)
Immobilization control
The immobilization control group will undergo arm immobilization. Immobilization will be implemented with four weeks of muscle unloading with a sling and swathe on the nondominant arm. The sling will suspend the arm at the elbow joint with the elbow in a flexed position at 90°, the swathe will then wrap around the participant to fix the arm against the body.
干预措施: Bilateral resistance training (Other)
Immobilization with unilateral training
The immobilization with unilateral training group will undergo arm immobilization for four with a sling and swathe on the nondominant arm. The sling will suspend the arm at the elbow joint with the elbow in a flexed position at 90°, the swathe will then wrap around the participant to fix the arm against the body. The free (non-immobilzed) arm of this group will undergo heavy strength training twice per week throughout the immobilization period. The training will consist of unilateral dumbbell shoulder press and biceps curl.
干预措施: Orthopedic immobilization (Procedure)
Immobilization with unilateral training
The immobilization with unilateral training group will undergo arm immobilization for four with a sling and swathe on the nondominant arm. The sling will suspend the arm at the elbow joint with the elbow in a flexed position at 90°, the swathe will then wrap around the participant to fix the arm against the body. The free (non-immobilzed) arm of this group will undergo heavy strength training twice per week throughout the immobilization period. The training will consist of unilateral dumbbell shoulder press and biceps curl.
干预措施: Unilateral resistance training (Other)
Immobilization with unilateral training
The immobilization with unilateral training group will undergo arm immobilization for four with a sling and swathe on the nondominant arm. The sling will suspend the arm at the elbow joint with the elbow in a flexed position at 90°, the swathe will then wrap around the participant to fix the arm against the body. The free (non-immobilzed) arm of this group will undergo heavy strength training twice per week throughout the immobilization period. The training will consist of unilateral dumbbell shoulder press and biceps curl.
干预措施: Bilateral resistance training (Other)
结局指标
主要结局
Changes in lean mass
时间窗: Changes from baseline at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 weeks
DEXA
Changes in isometric muscle strength
时间窗: Changes from baseline at 5 and 10 weeks
MVC (Newton)
Changes in dynamic muscle strength
时间窗: Changes from baseline at 5 and 10 weeks
1RM (lbs)
Changes in muscle size
时间窗: Changes from baseline at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 weeks
Ultrasound muscle thickness of biceps brachii and triceps brachii
Changes in EMG amplitude
时间窗: Changes from baseline at 5 and 10 weeks
Surface EMG
Changes in action potential amplitude
时间窗: Changes from baseline at 5 and 10 weeks
Surface EMG Decomposition
次要结局
未报告次要终点
研究者
Joshua Carr
Assistant Professor
Texas Christian University