NCT02229487已完成不适用
The Relationship Between Sleep and Glucose Tolerance in Prediabetes: the Role of GLP-1 in Short Sleepers
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- GLP-1 Levels in Response to Oral Glucose Tolerance Test
研究概览
简要总结
Hypothesis
- Prediabetes patients who have insufficient sleep will have worse glucose tolerance than those with normal sleep duration.
- Prediabetes patients with short sleep will have a delayed or reduced GLP-1 response to a standardized meal
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with prediabetes (HbA1c 5.7-6.4% or history of fasting plasma glucose 100-125 mg/dl) who receive medical care at Ramathibodi Hospital
- •Age 18 or older
- •Can understand Thai (speaking, listening and reading)
- •Agree to participate by written informed consent
排除标准
- •Those who depend on others for feeding (such as stroke patients)
- •Shift workers
- •History of congestive heart failure or low ejection fraction
- •Chronic obstructive pulmonary disease, end stage renal disease or chronic liver disease (AST or ALT > 3 times the upper limit of normal)
- •Use of medications: opioids/ narcotics , alpha blockers (prazosin, doxazosin, terazosin), clonidine, methyldopa, nitroglycerin
- •Patients with permanent pacemaker
- •History of previous stroke
研究组 & 干预措施
Normal Sleepers
Active Comparator
Prediabetes patients with normal sleep duration (7-8 hours/ night) as measured objectively
干预措施: Oral glucose tolerance (Other)
Short Sleepers
Experimental
Prediabetes patients with short sleep duration (<6 hours/night) as measured objectively
干预措施: Oral glucose tolerance (Other)
结局指标
主要结局
GLP-1 Levels in Response to Oral Glucose Tolerance Test
时间窗: 2 weeks
Prediabetes patients with and without short sleep will undergo an oral glucose tolerance test with measurement of GLP-1 levels
次要结局
未报告次要终点
研究者
Sirimon Reutrakul
Associate Professor
Ramathibodi Hospital
研究点 (1)
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