SARS-CoV-2 Specific Memory B and T- CD4+ Cells
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 主要终点
- Immunological memory: resolution of COVID-19 after SARS-CoV2 infection.
研究概览
简要总结
The current pandemic caused by the newly identified coronavirus responsible for COVID-19 is a major threat to our populations and societies.
Hypothesis/Objective The acquisition of protective immunity at the level of the individual, either through vaccination or natural resolution of the infection, progressively leads at the level of the population to the reduction of the fraction of the population that can be productively infected and transmit the virus, hence, leading to the diminution of the rate of transmission, a phenomenon called herd immunity. Herd immunity was proposed as a strategy to control the infection. However, it remains difficult to model group immunity given the limited knowledge of the interaction between the host immune system with the virus, whose capacity to evolve in face of a neutralizing response is also not known. It is therefore important to acquire a better knowledge of the immunological memory that ensures the resolution of COVID-19 after SARS-CoV2 infection.
Method To study single-cell B and T memory cells specific for the anti-SARS-CoV-2 response and characterize somatic mutations of immunoglobulin genes and TCR, in hospitalized and symptomatic patients and in patients cured of SARS-CoV-2.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who have recovered from CoV-2-SARS
- •Adult patient (≥ 18 years old) with a positive SARS-CoV-2 PCR.
- •Adult patient (≥ 18 years old) who has recovered from SARS-CoV-2 i.e. has been free of clinical symptoms for more than 15 days and has not been hospitalized and for less than 6 weeks.
- •Patient affiliated to a social security scheme.
- •Patients hospitalized for SARS-CoV-2
- •Adult patient (≥ 18 years old) with a positive SARS-CoV-2 PCR.
- •Adult patient (≥ 18 years old) with clinical symptoms for more than 3 days and hospitalized.
排除标准
- •Refusal of the patient to participate in the study.
- •Patient under guardianship / curatorship
结局指标
主要结局
Immunological memory: resolution of COVID-19 after SARS-CoV2 infection.
时间窗: 5 years
Biological blood collection: Blood samples taken in the course of the research will be part of a biological collection To study single-cell B and T memory cells specific for the anti-SARS-CoV-2 response and characterize somatic mutations of immunoglobulin genes and TCR, in hospitalized and symptomatic patients and in patients cured of SARS-CoV-2.
次要结局
未报告次要终点