Impact of Vitamin D Supplementation on Strength and Lean Mass Accumulation During an Exercise Intervention
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Muscle Function
研究概览
简要总结
The study was designed to assess the effects of vitamin D supplementation during exercise training on body composition, muscle function, and glucose tolerance. The investigators hypothesis for these studies is that vitamin D supplementation enhances exercise-induced increases in strength and lean mass, potentially through enhancing insulin sensitivity and reducing inflammation.
详细描述
The study was designed to assess the effects of vitamin D supplementation during exercise training on body composition, muscle function, and glucose tolerance. It was a double-blind, randomized, placebo-controlled, clinical trial with participants randomized into either a 4,000 IU/day vitamin D or placebo group and all participants completed 12 wks (3 d/wk) of exercise training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Physical activity scores in the "low" to "very low" category
- •Fitness estimations in the "below average" or lower categories
- •body mass index scores >24.9 indicating overweight or obesity.
排除标准
- •Use of tanning booths or other artificial UV light exposure
- •High baseline vitamin D and calcium intake
- •Plans to visit sunny/warm destinations during the winter months/study period
- •History or presence of metabolic disease, type 2 diabetes, eating disorders, gastrointestinal disorders, pregnancy or lactation
- •Use of drugs to treat obesity (last 12 weeks)
- •Use of over the counter anti-obesity agents (last 12 weeks)
- •Recent initiation of an exercise program (last four weeks).
研究组 & 干预措施
Vitamin D
Participants in this arm consumed a 4000 IU vitamin D supplement daily for 12 weeks while participating in a resistance exercise training program.
干预措施: Vitamin D (Dietary Supplement)
Placebo
Participants in this arm consumed a placebo (microcrystalline cellulose) daily for 12 weeks while participating in a resistance exercise training program.
干预措施: Vitamin D (Dietary Supplement)
Placebo
Participants in this arm consumed a placebo (microcrystalline cellulose) daily for 12 weeks while participating in a resistance exercise training program.
干预措施: Placebo (Drug)
结局指标
主要结局
Muscle Function
时间窗: three months
The primary endpoint is the change in lean mass (kilograms) after the three month resistance exercise intervention.
Glucose Tolerance
时间窗: three months
The primary endpoint is the change in the area under the glucose curve following an oral glucose tolerance test prior to and after the three month intervention.
Inflammation
时间窗: three months
The primary endpoint is the change in C reactive protein after the three month intervention
次要结局
未报告次要终点
研究者
Dorothy Teegarden
Associate Dean Research and Grad. Prof. College of HHS
Purdue University