Blood Pressure Lowering Effect of Low-frequency Transcutaneous Electrical Nerve Stimulation and Felodipin
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 41
- 试验地点
- 1
- 主要终点
- Blood pressure reduction
研究概览
简要总结
The purpose of this study is to compare the blood pressure reducing property of transcutaneous electrical nerve stimulation with the blood pressure reducing drug felodipin.
详细描述
Hypertension is a major risk factor for development of several vascular complications and is common world wide. Drug treatment is often necessary to achieve adequate blood pressure reduction but blood pressure control in studied countries is unsatisfactory low. Reasons for failure in treatment are several. Among others reasons intolerable side-effects may prevent successful treatment irrespective of the number of drugs.
Transcutaneous electrical nerve stimulation (TENS) constitutes no risk of interaction with pharmacological agents and previous studies have reported blood pressure reduction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •clinical diagnosis of hypertension, untreated or currently treated with a maximum of one blood pressure (BP) lowering agent
排除标准
- •systolic blood pressure >170 mmHg and/or diastolic blood pressure of >105 mmHg
- •second- or third-degree atrioventricular block
- •current use of opiates or other intoxicants
- •neurological disorders (such as Parkinson's disease, multiple sclerosis or peripheral neuropathy)
- •need of treatment with TENS, regardless the reason
研究组 & 干预措施
transcutaneous electr. nerve stimulation
干预措施: transcutaneous electrical nerve stimulation (Device)
felodipin
干预措施: felodipin (Drug)
结局指标
主要结局
Blood pressure reduction
时间窗: four weeks
Office blood pressure measurement and 24-h ambulatory blood pressure monitoring after four week periods of treatment in a cross-over design with intervening four week washout and subsequent four week follow-up
次要结局
未报告次要终点