Acceptance and Commitment Therapy vs. Cognitive Therapy for the Treatment of Major Depressive Disorder
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 82
- 试验地点
- 2
- 主要终点
- Hamilton Rating Scale for Depression
研究概览
简要总结
The study will investigate the effectiveness of Cognitive Therapy and Acceptance and Commitment Therapy in a randomized controlled trial among patients with Major Depressive Disorder in routine clinical practice. Furthermore, the study will investigate whether each specific treatment approach is mediated by its proposed theoretical mechanism.
详细描述
The current study aims at investigating the effectiveness of Cognitive Therapy and Acceptance and Commitment Therapy in a randomized controlled trial among patients with MDD in routine clinical practice. Further, the study will investigate whether each specific treatment approach is mediated by its proposed theoretical mechanism. Patients have to meet diagnostic criteria for nonpsychotic MDD as determined by the Structured Interview for DSM-IV. Each client will receive either Cognitive Therapy or Acceptance and Commitment Therapy that will last between 16 to 20 sessions. Based on previous results, it is expected that both treatment forms will prove beneficial for the patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meeting DSM-IV criteria for MDD
- •Between the ages of 18 and 65-years-old
- •Having sufficient fluency in Dutch to complete treatment and research protocol
排除标准
- •DSM-IV criteria for bipolar disorder (past or present)
- •Psychotic disorders
- •Substance dependence disorders (current or within the past 6 months), or
- •Organic brain syndrome.
- •Borderline or antisocial personality disorder
结局指标
主要结局
Hamilton Rating Scale for Depression
时间窗: pre-treatment, post-treatment
Change from pre-treatment to post-treatment.
QUICK INVENTORY OF DEPRESSIVE SYMPTOMATOLOGY (QIDS-SR)
时间窗: pre-treatment, post-treatment, 6 and 12 months follow-up
Change from pre-treatment to post-treatment, 6 months follow-up and 12 months follow-up
次要结局
- Working Alliance Inventory(3. session)
- Eurohis Quality of Life Scale(Pre-, post-treatment, 6 and 12 months follow-up)
- Structured Clinical Interview for DSM-IV (Major Depression Module)(Pre-treatment and post-treatment.)
- Acceptance and Action Questionnaire(Pre-treatment, in-treatment, and 6 and 12 months follow-up.)
- Decentering subscale of the Experiences Questionnaire(Pre-treatment, in-treatment, and 6 and 12 months follow-up.)
- Dysfunctional Attitude Scale-revised(Pre-treatment, in-treatment, and 6 and 12 months follow-up)
- Implicit Attitude Test(Pre- and posttreatment)
- Relationship Scales(Pre-, post-treatment, 12 months follow-up)
研究者
Paul M.G.Emmelkamp
Professor
VU University of Amsterdam