Evaluation of Immunological Disorders of T Lymphocytes and Endocrinological Disorders as Pathogen Factors in Patients With Metaplasia of Urinary Bladder
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- Symptoms of stratified squamous metaplasia of urinary bladder and treatment's ways
研究概览
简要总结
Background: Squamous metaplasia refers to the pathological transformation of the urothelium leading to non-keratinised stratified squamous metaplasia (N-KSM).
Objective: To present the investigators experiences in the diagnosis and treatment of N-KSM of the urinary bladder in children.
详细描述
Design, setting, and participants: In this study, the investigators present their experiences in the diagnosis and treatment of N-KSM of the urinary bladder in children aged from 5 to 17 years. From 2005 to 2013, metaplasia was diagnosed in 119 patients - 116 girls and 3 boys. The reasons behind visiting the hospital were non-specific intense pain in the abdomen, recurrent urinary tract infections, and urination disorders. The most common symptoms of urinary bladder dysfunction were pollakiuria and difficulties in initiating micturition and retention of urine (reduced detrusor muscle activity).
Outcome measurements and statistical analysis: In 20 patients (16.8%), metaplasia was incidentally diagnosed during cystoscopy performed for other causes. Only the children whose bladders showed metaplastic changes on cystoscopy were subjected to a bladder biopsy for collecting specimens for further histopathological examination.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 5 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The follow-up duration was 1-8 years.
- •The main reasons behind visiting the hospital were:
- •recurrent urinary tract infection,
- •urinary urgencies,
- •pollakiuria,
- •difficulty in initiating micturition,
- •pain in hypogastrium,
- •night wetting and day wetting,
- •menstruation's disorders,
- •urolithiasis,
- •defects of urinary system and hematuria.
排除标准
- •No confirmation of squamous metaplasia of the urinary bladder in diagnostic cystoscopy
研究组 & 干预措施
Female 1
Owing to the absence of an established treatment modality for squamous metaplasia of the urinary bladder in children, we developed our own treatment modalities. Children presenting with recurrent urinary tract infections on medical interview, were subjected to ultrasonography of the urinary system, repeated urinalysis, and urine culture tests. Then, on the basis of antibiogram findings, antibiotic and chemotherapeutic treatment was administered to eliminate the bacteriological factors. Second-generation cephalosporin was prescribed for 10 days, and then treatment crossover with chemotherapeutics in therapeutic dose (change in every week) during 3 months.
干预措施: Second-generation cephalosporin, nitrofurantoin, 1% aminoglycoside solution (Drug)
Male 2
Owing to the absence of an established treatment modality for squamous metaplasia of the urinary bladder in children, we developed our own treatment modalities. Children presenting with recurrent urinary tract infections on medical interview, were subjected to ultrasonography of the urinary system, repeated urinalysis, and urine culture tests. Then, on the basis of antibiogram findings, antibiotic and chemotherapeutic treatment was administered to eliminate the bacteriological factors. Second-generation cephalosporin was prescribed for 10 days, and then treatment crossover with chemotherapeutics in therapeutic dose (change in every week) during 3 months.
干预措施: cephalosporin with chemotherapeutics (Drug)
结局指标
主要结局
Symptoms of stratified squamous metaplasia of urinary bladder and treatment's ways
时间窗: 5 years
次要结局
未报告次要终点
研究者
Beata Jurkiewicz
PhD MD
Children's Hospital, Dziekanów Leśny, Poland