NCT00750048已完成1 期
Impact of Naloxone on the Analgesic Effect of Paracetamol in Healthy Volunteers
University Hospital, Clermont-Ferrand2 个研究点 分布在 1 个国家目标入组 12 人开始时间: 2008年9月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Variation of amplitude of the N2P2 cerebral wave (before and after administration of Naloxone) induced by thermal stimulus applied on the arm.
研究概览
简要总结
The aim of this study is to check if Naloxone induce an inhibiting effect on the analgesic effect of paracetamol in healthy volunteer, using evoked potentials.
详细描述
Double Blind, cross-over study in healthy volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy men
- •between 18 and 40 years old
- •written consent given
排除标准
- •Naloxone or paracetamol hypersensibility
- •Excessive consumption of alcohol, tobacco, coffee, tea or toxicomania
- •Concomitant medication
结局指标
主要结局
Variation of amplitude of the N2P2 cerebral wave (before and after administration of Naloxone) induced by thermal stimulus applied on the arm.
时间窗: before and after administration of Naloxone
次要结局
- Follow up of pain's evaluation using analogical visual scale. Follow up of pain's evaluation using analogical visual scale(following the pain's evaluation)
研究者
研究点 (2)
Loading locations...
相似试验
招募中
3 期
Intramuscular Naloxone in methadone overdoseIRCT20120629010133N6Shahid Beheshti University of Medical Sciences398
Unknown
不适用
Subjective Analgesic Effects of Naloxone and Virtual RealityPainNCT01105871University of Washington50
尚未招募
3 期
Effect of ultra-low dose Naloxone on paiCholecystitisIRCT20230424057986N1Iran University of Medical Sciences60
进行中（未招募）
不适用
The effect of naloxon, a drug that removes the effect of morfin), on pain hypersensitivity after a inguinal herniotomy operation.First degree burn injury in healthy volunteers who 6-8 weeks prior have had done a Inguinal herniotomy .MedDRA version: 16.1Level: LLTClassification code 10049475Term: Chronic painSystem Organ Class: 100000004867EUCTR2013-004709-17-DKRigshospitalet
终止
3 期
Naltrexone in Borderline Personality DisorderBorderline Personality DisorderNCT00124839Central Institute of Mental Health, Mannheim48