Hypoglycemic Potential of Garcinia Cambogia (Garcinia Gummi-gutta (L.) N.Robson) Rind Powder Among Pre-diebetic Obese Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Weight
研究概览
简要总结
Garcinia cambogia, rich in hydroxycitric acid (HCA), has been suggested to promote weight loss and improve metabolic parameters. Evidence regarding its efficacy in pre-diabetic obese adults remains limited.
Objective: To evaluate the effects of Garcinia cambogia rind powder supplementation on anthropometric, glycemic, lipid, hepatic, and renal parameters in pre-diabetic obese adults.
详细描述
The observed effects are likely mediated by HCA, which inhibits ATP-citrate lyase, reducing de novo lipogenesis, enhancing glucose utilization, and modulating adipokines and oxidative stress.
Conclusion: Garcinia cambogia rind powder supplementation exerts dose-dependent metabolic benefits in pre-diabetic obese adults, improving anthropometric, glycemic, lipid, hepatic, and renal parameters without adverse effects. It may serve as a complementary intervention alongside lifestyle modification for the management of obesity and pre-diabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants of both genders were included if they were aged 30-60 years,
- •body mass index (BMI) ≥30 kg/m²,
- •Individuals with HbA1c levels ranging from 5.7% to 10% were selected, .indicating pre-diabetic to diabetic status. Participants were required to have a .body mass index (BMI) of 25 kg/m² or higher
排除标准
- •Participants who were diagnosed with type 1, pregnant or lactating,
- •chronic liver, kidney, or cardiovascular disease,
- •history of hepatotoxicity or gastrointestinal disorders,
- •using weight-loss supplements, steroids, or lipid-lowering drugs, or had a known allergy to Garcinia cambogia
研究组 & 干预措施
Placebo group
Starch capsule once a day
干预措施: Garcinia cambogia rind powder (Dietary Supplement)
T1
100mg/day of Garcinia cambogia rind powder
干预措施: Garcinia cambogia rind powder (Dietary Supplement)
T2
200mg/day of Garcinia cambogia rind powder
干预措施: Garcinia cambogia rind powder (Dietary Supplement)
结局指标
主要结局
Weight
时间窗: 12 weeks
次要结局
- Lipid profile(12 weeks)
- fasting glucose(12 weeks)