Microablative CO2 laser versus Fractionated Microablative Radiofrequency in the treatment of Genitourinary Menopause Syndrome: a controlled, randomized, double-blind, non-inferiority clinical trial

niversidade Brasil0 个研究点开始时间: 2023年2月7日最近更新: 2023年5月29日

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•Physiologically postmenopausal women with amenorrhea longer than one year and plasma follicle-stimulating hormone dosage greater than 40 U/l and estradiol less than 25 pg/mL. Age between 50 and 70 years. Present clinical symptoms of the menopausal genitourinary syndrome. Current cervical cytological exam performed in the last six months negative for neoplasia

•Women who have received any form of hormone replacement therapy in the past six months. Women who have used non-hormonal vaginal lubricants or moisturizers in the past month. Presence of active genital infections. Patients with a history of genital herpes who are unwilling to take oral Acyclovir prophylaxis. Women who have chronic inflammatory diseases that make the procedures unfeasible. Carriers of thrombophilia or regular users of anticoagulants or platelet antiaggregants. Patients that present vaginal prolapse of second or third degree according to the Pelvic Organ Prolapse Quantification System. Patients with a history of photosensitivity. Those who have had previous treatment with endovaginal CO2 laser or micro ablative Radiofrequency in any period

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niversidade Brasil