NCT00356629终止不适用
Development of a Noninvasive Method of Evaluation of the Pulmonary Inflammation in the Condensates of Exhaled Air
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 100
- 试验地点
- 1
研究概览
简要总结
The aim of the study is identify biological parameters reflecting proteolytic activity in the exhaled condenstaes which might be useful to follow up pulmonary inflammation in various conditions including cystic fibrosis, COPD, asthma, tobacco exposure. Three proteases will be analyzed, i.e. elastase, proteinase 3 and cathepsin G. Results in the condensates will be compared to those obtained in sputum.
详细描述
5 groups of 20 individuals each: group 1 CF, group 2 COPD, group 3 asthma, group 4 tobacco exposure, group 5 control subjects.
Collection of exhaled condensates in all subjects and of sputum in subjects belonging to groups 1 and 2.
Clinical examination and PFTs in all patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •acute exacerbation of the disease during the last 2 weeks
- •IV or oral steroids or antibiotics during the last 2 weeks
- •hospitalization during the last 2 weeks
- •colonization by S aureus methicillin resistant and/or Burkholderia cepacia
研究者
研究点 (1)
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