NCT02854046已完成不适用
Calciphylaxis : Population, Risk Factors, Diagnostic Practice, Therapeutic and Outcome : a Multicentric, Retrospective Cohort
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Description of calcific uremic arteriolopathy in a French population by describing the characteristics of the population, diagnostic and treatment practices and patient outcome.
研究概览
简要总结
Calciphylaxis, also called Calcific Uremic Arteriolopathy (CUA) is a lethal affection mostly affecting patient in end stage renal disease. The survival rate is described around 20 to 46% at one year.
Clinical presentation is very painful skin lesions with ulceration mostly located on the trunk or thigh.
Current knowledge about physiopathology, diagnostic practice and therapeutic is very limited.
Actually there is no European study about calciphylaxis and risk factors, diagnostic practice and outcome factors.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients ≥ 18 years with chronic renal failure with Glomerular Filtration Rate < 30ml/min/1,73m²
- •diagnosis of calciphylaxis between 2006 and 2016
- •living in the Regions of Bretagne, Pays de la Loire, Poitou-Charentes or Centre Val de Loire.
排除标准
- •realized biopsy in favor of differential diagnosis
- •significant arterial lesion of lesion area or differential diagnosis more valid
- •if the diagnosis is not based on the following criteria: 3 clinical criteria or 2 clinical criteria and biopsy in favor, criteria which are :
- •Patient in chronic hemodialysis or stade 4 chronic kidney disease
- •At least 2 painful sores and hardly curable with concomitant painful purpura
- •Sore and purpura localisation in trunk, extremities and penis.
结局指标
主要结局
Description of calcific uremic arteriolopathy in a French population by describing the characteristics of the population, diagnostic and treatment practices and patient outcome.
时间窗: Up to 16 months
次要结局
- Study factors determining the patient outcome with calciphylaxis(Up to 16 months)
- Study case control of risk factors in the subgroup of patients in extra renal replacement therapy(Up to 16 months)
研究者
研究点 (1)
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