The Effects of L-Tyrosine on Non-invasive Ambulatory Blood Pressure and Heart Rate Monitoring in Parkinson's Disease
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Blood Pressure
研究概览
简要总结
The investigators are observing the effects 2,000 mg of L-tyrosine will have on 24 hour blood pressure fluctuations in individuals with Parkinson's disease.
详细描述
We will be monitoring 24 hour ambulatory BP and HR in subjects with PD on 3 separate visits. The first visit will be without an intervention to establish a baseline of 24 hour BP fluctuations. One week later the subject will be given either L-tyrosine (2,000 mg) with B6 (10 mg) or a sugar pill. We will monitor 24 hour BP and HR after supplementation. One week later the subject will repeat the same procedures with either supplement or placebo.
This is a total of 3 visits with 24 hour ambulatory BP and HR monitoring.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 84 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All subjects must have a diagnosis of PD by a licensed neurologist according to the UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria (UKPDBB).(Goetz, 2010) The UKPDBB is a 3 step diagnostic tool which defines inclusion and
排除标准
- •for diagnosing PD
- •between 35 and 79 years of age
- •mentally able to participate in the study
- •Exclusion Criteria:
- •any person who is currently taking amino acid supplements.
- •Any history of myocardial infarction, stent, or CABG
- •Phenylketonurics
- •Untreated hypertension
研究组 & 干预措施
Sugar Pill
We will administer a sugar pill BID for 24 hours and record BP and HR.
干预措施: L-tyrosine (Dietary Supplement)
Sugar Pill
We will administer a sugar pill BID for 24 hours and record BP and HR.
干预措施: Sugar Pill (Dietary Supplement)
L-Tyrosine
We will administer 1,000 mg of L-tyrosine BID for 24 hours and record BP and HR.
干预措施: Sugar Pill (Dietary Supplement)
L-Tyrosine
We will administer 1,000 mg of L-tyrosine BID for 24 hours and record BP and HR.
干预措施: L-tyrosine (Dietary Supplement)
结局指标
主要结局
Blood Pressure
时间窗: 24 hours
次要结局
- Heart Rate(24 hours)
研究者
Joanne DiFrancisco-Donoghue
Associate Professor
New York Institute of Technology