Imaging of Cortical Dopamine Transmission in Cocaine Dependence
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Percent change in Binding potential (BPnd)
研究概览
简要总结
The goal of this study is to use [C-11]FLB 457 and amphetamine (oral, 0.5 mg/kg) to measure cortical dopamine transmission in cocaine dependent individuals and healthy controls
详细描述
This study seeks to examine dopamine (DA) transmission in vivo, using positron emission tomography (PET) with [C-11]FLB 457, in cortical regions of interest in subjects who have a history of cocaine dependence. We hypothesize that cocaine dependence is associated with decreases in dopamine in the prefrontal cortical regions compared to controls. This may explain the impulsivity and cognitive deficits that underlie relapse in this disorder.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Cocaine dependence
[C-11]FLB 457 PET at baseline and post d-amphetamine
干预措施: d-amphetamine (Drug)
Cocaine dependence
[C-11]FLB 457 PET at baseline and post d-amphetamine
干预措施: [C-11]FLB 457 (Radiation)
Controls
[C-11]FLB 457 PET at baseline and post d-amphetamine
干预措施: d-amphetamine (Drug)
Controls
[C-11]FLB 457 PET at baseline and post d-amphetamine
干预措施: [C-11]FLB 457 (Radiation)
结局指标
主要结局
Percent change in Binding potential (BPnd)
时间窗: Baseline BPnd (time 0) and Post-amphetamine BPnd (time 3 hours)
DELTA BPnd
次要结局
未报告次要终点
研究者
Rajesh Narendran
Visiting Professor in Radiology
University of Pittsburgh