Ghrelin Expression Could Regulate Diastolic Heart Function in Obese Patients With Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- normalization of LV diastolic dysfunction
研究概览
简要总结
In type 2 diabetes mellitus (T2DM) and obese patients the adipose tissue could over-express cytokines, sirtuin-1 (SIRT1), and microRNAs (miRs) implied in the regulation of left ventricle (LV) diastolic function (LV-DF). Ghrelin could modulate these pathways. Thus, in the current study authors will investigate ghrelin expression in T2DM obese patients after abdominal fat excision, and particularly in those with normalization of LV-DF at 1 year of follow-up.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of T2DM obese patients;
- •T2DM obese patients under anti-diabetic full medical therapy and glycemic control.
排除标准
- •clinical diagnosis of type 1 diabetes;
- •T2DM patients in poor glycemic control (HbA1c values of >7%);
- •chronic neurological disorders;
- •heart failure and coronary heart disease or depression of left ventricular ejection fraction (LVEF <55%);
- •severe anemia;
- •thyroid dysfunction;
- •kidney failure;
- •uncontrolled blood pressure (blood pressure > 140/90 mmHg on two occasions 2 weeks apart);
- •inflammatory chronic disease;
- •neoplastic disease.
结局指标
主要结局
normalization of LV diastolic dysfunction
时间窗: 12 months
At 1 year of follow-up authors evaluated the patients (those with first and second degree of LV diastolic dysfunction) that will experience the normalization of LV diastolic function.
次要结局
未报告次要终点
研究者
Celestino Sardu
Professor of Medicine
University of Campania "Luigi Vanvitelli"