The Associations Analysis Between Lifestyle and Osteoporosis Among Chinese Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 3,100
- 试验地点
- 2
- 主要终点
- osteoporosis accessed by Bone Mass Density (BMD)
研究概览
简要总结
A large-scale, community-based, cross-sectional study was conducted to evaluate the extent to which lifestyle was associated with osteoporosis among the Chinese population by using self-reported questionnaire methods.
详细描述
A large-scale, community-based, cross-sectional study was conducted to evaluate the extent to which lifestyle was associated with osteoporosis among the Chinese population by using self-reported questionnaire methods. More than 3000 participants were recruited in communities in Shanghai. Data involved in demographic information, lifestyle, dietary habits, medical history and clinical biomarkers were collected. Every participants were measured bone mineral density (BMD g/cm2) at calcaneus by standardized quantitative ultrasound (QUS, Hologic Inc., Bedford, MA, USA) utilizing T-scores based on WHO criteria. A standard statistical analysis including univariate and multiple variables regression analysis to explore the risk or preventive factors involved in Chinese lifestyle associated with osteoporosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 30 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants aged 30-90 years were recruited from rural and urban communities in Shanghai.
排除标准
- •Some participants with chronic diseases and conditions that might potentially affect bone mass, structure, or metabolism were excluded. Briefly, the exclusion criteria were as follows: a history of
- •serious residual effects of cerebral vascular disease;
- •serious chronic renal disease (Glomerular filtration rate - GFR < 30 mL/min/1.73m2);
- •serious chronic liver disease or alcoholism;
- •significant chronic lung disease;
- •corticosteroid therapy at pharmacologic levels;
- •evidence of other metabolic or inherited bone disease, such as hyper- or hypoparathyroidism, Paget disease, osteomalacia, or osteogenesis imperfecta;
- •recent (within the past year) major gastrointestinal disease, such as peptic ulcer, malabsorption, chronic ulcerative colitis, regional enteritis, or significant chronic diarrhea;
- •Cushing syndrome;
- •hyperthyroidism; and
- •any neurologic or musculoskeletal condition that would be a non-genetic cause of low bone mass.
结局指标
主要结局
osteoporosis accessed by Bone Mass Density (BMD)
时间窗: participants will be measured for the duration of outpatient stay, an expected average of 2 weeks
The bone mineral density (BMD g/cm2) was measured at calcaneus by standardized quantitative ultrasound (QUS, Hologic Inc., Bedford, MA, USA) utilizing T-scores based on WHO criteria, which were obtained from the automated equipment. T-score refers to the ratio between patient's BMD and that of young adult population of same sex and ethnicity. T-score of \> -1 was taken as normal, between -1 and -2.5 osteopenic and \< -2.5 as osteoporotic.
次要结局
未报告次要终点
研究者
Zihui Tang
M.D and Ph.D
Huashan Hospital