NL-OMON45176已完成不适用
Effects of resveratrol on insulin sensitivity, brown adipose tissue and metabolic profile in first-degree relatives of type 2 diabetic patients - Resveratrol and pre-diabetes
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
研究概览
简要总结
Trial is onging in other countries
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •* Male sex
- •* Age: 40-70 years
- •* BMI 27-35 kg/m2
- •* Has first-degree relative(s) diagnosed with type 2 diabetes
- •* Sedentary:
- •o Not more than 2 hours of sports a week
- •o No active job that requires strenuous physical activity
- •* Stable dietary habits: no weight gain or loss > 5kg in the last three months
- •* Insulin resistant: glucose clearance rate <350 ml/kg/min, as determined using OGIS120
- •* Willingness to abstain from resveratrol-containing food products
- •* Subjects will only be included when the dependent medical doctor of this study approves participation after evaluating data obtained during screening
排除标准
- •* Use of anticoagulants
- •* Uncontrolled hypertension
- •* Haemoglobin <7.8 mmol/l
- •* In case of an abnormal ECG at rest: this will be discussed with the responsible medical doctor
- •* HBA1C > 6.5%
- •* Diagnosed with type 2 diabetes
- •* Medication use known to interfere with glucose homeostasis/metabolism
- •* Current alcohol consumption > 20 grams/day
- •* Subjects who don*t want to be informed about unexpected medical findings during the screening /study, or do not wish that their physician is informed, cannot participate in the study.
- •* Subjects who intend to donate blood during the intervention or subjects who have donated blood less than three months before the start of the intervention.
- •* Participation in another biomedical study within 1 month before the screening visit
- •* Any contra-indication to MRI scanning:
- •o Central nervous system aneurysm clip
- •o Implanted neural stimulator
- •o Implanted cardiac pacemaker of defibrillator
- •o Cochlear implant
- •o Insulin pump
- •o Metal containing corpora aliena in the eye or brains
- •For the 18F-FDG PET-CT scan:
- •o Participation in earlier research or medical examinations that included PET/CT scanning
研究者
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