Substance Misuse To Psychosis for Ketamine (SToP-K) -Who is At Risk? A Case-Control Study in Ketamine and Non-Ketamine-Using Substance Abusers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 162
- 试验地点
- 2
- 主要终点
- relative risk of ketamine users compared to non-ketamine using drug user to develop psychosis
研究概览
简要总结
Evidence suggests that repeated or chronic ketamine use, as compared to acute ketamine users, posed a higher clinical risk of developing psychotic disorders, potentially related to the underlying chronic N-methyl-D-aspartate receptor (NMDAR) dysfunction, and a higher risk of suffering from schizophrenia particularly in those genetically susceptible, or genetically predisposed ketamine abusers. With ketamine infusion rises as a emerging hope as an acute treatment for depression and suicidality under the shadow of unknown longer term psychotomimetic effects peculiarly amongst repeated or chronic use, the current case-control study aims to investigate: a) if repeated or chronic ketamine use is associated with an increased risk of psychosis by comparing those ketamine abusers with and without psychosis, and to those non-ketamine-using drug abusers with psychosis; and b) if genetic predisposition from single nucleotide polymorphisms are associated with risk of psychosis in ketamine abusers.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 12 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: 12 - 65 years old
- •Able to read and communicate in English and/or Chinese
- •Able to give informed consent
- •Self-reported to have psychoactive substance use continuously for ≥3 month
- •At least one positive urine toxicology result showing the reported psychoactive substance being used
排除标准
- •Age <12 years old
- •Unable to read English or Chinese
- •Unable to give informed consent
- •Had been diagnosed to have Intellectual Disabilities (DSM-5) or Mental Retardation (ICD-10, F70-73)
- •Had been diagnosed to have primary psychosis prior to the use of any psychoactive substances, including alcohol
- •Had been diagnosed to have "bipolar and related disorder" prior to the use of any psychoactive substances, including alcohol
- •Had been diagnosed to have "major depressive disorder with psychotic features" prior to the use of any psychoactive substances, including alcohol
- •Had been diagnosed to have "psychotic disorder due to another medical condition" (DMS-5)
- •Self-reported to have abstained from any psychoactive substance use continuously for ≥12 months AND with negative urine toxicology result at the time of recruitment/ intake at the psychiatric services as recorded on case notes
结局指标
主要结局
relative risk of ketamine users compared to non-ketamine using drug user to develop psychosis
时间窗: During the 2 year study period
relative risk of ketamine users compared to non-ketamine using drug user to develop psychosis
次要结局
- Gene association to development of psychcosis(During the 2 year study period)
研究者
Dr. Albert Kar-Kin Chung
Clinical Assistant Professor
The University of Hong Kong