The Effect of Acute Heat Exposure on Glucose Use During Moderate-intensity Exercise in People With Type 1 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 38
- 试验地点
- 1
- 主要终点
- blood glucose
研究概览
简要总结
A randomised, crossover, counterbalanced repeated measures study will be conducted to examine the effect of acute heat exposure on rate of change in blood glucose concentration during 40 minutes of moderate-intensity exercise and for 30 minutes after exercise. Participants will complete two experimental conditions during two separate laboratory visits, with the order of conditions randomised. One condition will be a temperate condition of 20°C with 50% relative humidity (Temperate), the other will be 40°C with 50% relative humidity (Heat). Visits will be identical, including time of day, except for the condition. Visits will be separated by 24h. Testing will take place in the laboratories of the Research Institute for Sport and Exercise Sciences at Liverpool John Moores University.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •T1D diagnosis more than 1 years ago (to ensure participants are out of the honeymoon period)
- •Using insulin therapy with multiple daily injections (MDI), insulin pump (pump), or hybrid closed-loop (HCL)
- •o If using a HCL system have experience of using a pre-programmed basal rate in manual mode during exercise
- •Aged 18-65 years
- •Regularly engaged in endurance exercise (training at least twice per week for ≥30 minutes per session)
排除标准
- •Pregnancy
- •<6 months postpartum or stopped breastfeeding <1 month before recruitment
- •Existing cerebrovascular or cardiovascular disease
- •Significant history of hyperglycaemia (HbA1c >85 mmol/mol)
- •History of severe hypoglycaemia requiring third party assistance within the last 3 months
- •Body weight <36.5kg
- •Difficulty swallowing tablets
- •Appointment for an MRI test that cannot be rescheduled
- •Obstructive gastrointestinal disease
- •History of gastrointestinal surgery
- •Have an implanted medical device
研究组 & 干预措施
Temperate
40 minutes of moderate intensity continuous exercise at 20°C with 50% relative humidity
干预措施: Exercise (Behavioral)
Heat
40 minutes of moderate intensity continuous exercise at 40°C with 50% relative humidity
干预措施: Exercise (Behavioral)
结局指标
主要结局
blood glucose
时间窗: Baseline pre exercise to end of exercise (40 minutes)
change in blood glucose concentration
次要结局
- Core temperature(Baseline pre exercise to end of exercise (40 minutes))
- Skin temperature(Baseline pre exercise to end of exercise (40 minutes))
- Free fatty acids(Baseline pre exercise to end of exercise (40 minutes))
- insulin(Baseline pre exercise to end of exercise (40 minutes))
- glucagon(Baseline pre exercise to end of exercise (40 minutes))
- epinephrine(Baseline pre exercise to end of exercise (40 minutes))
- norepinephrine(Baseline pre exercise to end of exercise (40 minutes))
- cortisol(Baseline pre exercise to end of exercise (40 minutes))
- Growth hormone(Baseline pre exercise to end of exercise (40 minutes))
- lactate(Baseline pre exercise to end of exercise (40 minutes))