Effect of Thyroid Disorders in Metabolic Fatty Liver Changes
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 140
- 主要终点
- Detect correlation between hyperthyroid diseases and NASH .
研究概览
简要总结
Aims of the Research
- To detect correlation between hyperthyroidism and non alcoholic fatty liver disease (NAFLD).
- To detect hepatic risk in subclinical and clinical hypothyroidism .
- To detect early liver disorders in thyroid disorders using fibroscan .
详细描述
Non alcoholic fatty liver disease (NAFLD) has been a health problem of growing significance all over the world; its prevalence is increasing in both developed and developing countries ,the overall prevalence of NAFLD worldwide was estimated to be 32.4%.prevalence increased significantly over time.
considering the increasing incidence of NALAD/NASH, especially in developed and developing countries, it is anticipated that cirrhosis due to these conditions may exceed other causes of cirrhosis in a near future..
Thyroid gland is involved in energy homeostasis, lipid and carbohydrate metabolism, regulation of body weight and adipogenesis.
In a clinical setting, subclinical hypothyroidism has been associated with metabolic syndrome, cardiovascular mortality and disturbance of lipid metabolism.
The prevalence of hypothyroidism was reported to 16.8% among patients with NAFLD/NASH.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The study will include thyroid patients over one year duration ( age above 18 years old
排除标准
- •History of liver failure or patient known to have congenital liver disease.
- •Medications associated with weight gain .
- •Patients who have diabetes mellitus.
- •patients who already have liver disease eg; chronic viral hepatitis, liver cirrhosis.
- •Patients on antistatin.
结局指标
主要结局
Detect correlation between hyperthyroid diseases and NASH .
时间窗: Baseline
Test the patients of thyroid disorders for metabolic fatty liver changes
次要结局
未报告次要终点
研究者
Tasneem Mohammed Ali
Principal investigator
Assiut University