Effects of CPAP on Nitrate and Norepinephrine Levels in Severe and Mild-moderate Sleep Apnea
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 67
- 试验地点
- 1
- 主要终点
- Plasma nitrate (NOx) levels
研究概览
简要总结
Reduced plasma nitrate (NOx) levels and increased urinary norepinephrine (U-NE) levels have been described in severe obstructive sleep apnea (OSA), and are reverted by continuous positive airway pressure (CPAP). The investigators wanted to know the effect of CPAP on these biomarkers in mild-moderate OSA.
详细描述
The investigators aimed to compare NOx and U-NE levels and blood pressure (BP) between male patients with mild-moderate and severe OSA and determine the impact of 1 month of CPAP therapy on these parameters.
The investigators undertook a prospective study of 67 consecutive OSA patients (36 mild-moderate, 31 severe). Measurements of plasma NOx at 11 pm, 4 am and 7 am, 24-h U-NE and ambulatory BP were obtained at baseline and after 1 month of CPAP.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of obstructive sleep apnea
排除标准
- •current smoker
- •respiratory disease
- •cardiac disease (except for arterial hypertension)
- •renal disorder
- •hepatic disorder
- •psychiatric disorder
- •diabetes mellitus
- •dyslipidemia
- •sinusitis
- •acute illness
- •daytime hypoxemia or hypercapnia
- •therapy with oral nitrates
- •therapy with angiotensin-converting enzyme inhibitors
- •therapy with beta-blockers
- •therapy with statins
- •therapy with non-steroidal anti-inflammatory drugs
- •presence of central respiratory events
- •previous CPAP therapy
- •previous uvulopalatopharyngoplasty
研究组 & 干预措施
CPAP treatment
67 consecutive male patients with OSA were recruited: 36 with mild-moderate OSA and 31 with severe OSA. Data were collected in all subjects at baseline and after 1 month of CPAP.
干预措施: CPAP (Device)
结局指标
主要结局
Plasma nitrate (NOx) levels
时间窗: one month
After sleep apnea diagnosis, measurements of plasma NOx at 11 pm, 4 am and 7 am were obtained at baseline and after 1 month of CPAP.
次要结局
- 24 h Blood pressure(one month after CPAP)
- Urinary norepinephrine (U-NE) levels(One month)