Clinical and Laboratory Predictors of Chronic Pain After Critical Illness: A Prospective Analysis of Intensive Care Unit Survivors
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Chronic pain
研究概览
简要总结
Thanks to medical advances, more patients now survive their stay in the Intensive Care Unit (ICU). However, many people who leave the ICU face long-term health problems, known as Post-Intensive Care Syndrome (PICS). This can include physical weakness, memory or thinking problems, anxiety or depression - and chronic pain.
Chronic pain is pain that lasts more than 12 weeks and can interfere with your daily life. Studies show that many ICU survivors still experience moderate to severe pain even a year after they go home, especially in the shoulders. This pain is often linked to conditions like severe infections or older age, but it's not yet fully understood.
To help improve care, researchers at Attikon University Hospital in Athens are studying ICU survivors to learn:
How common chronic pain is
Where it appears in the body
How severe it is
How it affects everyday activities
They are also looking at health history, treatments received in the ICU, and lab results to see if any of these are linked to pain after discharge.
If you or your loved one has been in the ICU and experiences ongoing pain, know that you're not alone - and that researchers and doctors are working to better understand and manage this problem.
详细描述
Over the past two decades, improved intensive care practices have significantly reduced in-hospital mortality. However, a growing number of survivors experience a range of long-term complications, collectively known as Post-Intensive Care Syndrome (PICS). A key but underexplored component of PICS is chronic pain, defined as persistent pain lasting beyond 12 weeks or beyond the expected healing time following trauma or surgery.
Existing data suggest that up to 73% of ICU survivors report moderate to severe pain one year after discharge, with the shoulder being the most commonly affected anatomical region. Retrospective studies estimate the prevalence of chronic pain among ICU survivors to be as high as 44%. Identified risk factors include advanced age and severe sepsis; however, there is limited evidence regarding the true impact of chronic pain on activities of daily living (ADLs), its intensity, and clinical predictors.
This prospective observational study is conducted at the Intensive Care Unit of Attikon General University Hospital in Athens, Greece, and includes both medical and surgical ICU patients, including cardiothoracic surgery cases. The aim is to assess the prevalence, anatomical distribution, and intensity of chronic pain in ICU survivors, examine its interference with daily functioning, and explore associations between chronic pain and clinical or laboratory data collected during ICU admission, hospitalization, and discharge.
Patients are evaluated at three timepoints: ICU admission, ICU discharge, and three months post-ICU discharge. The inclusion criteria are age ≥18 years and ICU stay of at least 24 hours.
Detailed data collection includes:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age greater than 18 years old and
- •A minimum of one day of intensive care unit (ICU) hospitalization
排除标准
- •Age less than 18 years old
结局指标
主要结局
Chronic pain
时间窗: three months post discharge
Assement of chronic pain via questionnaire (Short-form McGill Pain Questionnaire)
次要结局
未报告次要终点
研究者
Milionis Orestis
Principal Investigator
Attikon Hospital