Quality of Life and Patient Needs in Advanced High Grade Gliomas - A Prospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 55
- 主要终点
- Examination
研究概览
简要总结
There is limited knowledge regarding the quality of life and needs of patients with advanced high grade gliomas, especially during the end of life. By doing this research, we are able to assess caregiver and patient symptoms and needs during the end of life phase of patients with brain tumors.
详细描述
Purpose: This is a pilot study to prospectively assess the symptoms and quality of life of patients and with advanced high grade glioma and their care takers.
Specific Aims: The aim of this study is to investigate the symptoms of patients with advanced high grade glioma. Patients who failed 3rd line chemotherapy and who require at least occasional assistance will be prospectively followed and their symptoms will be prospectively assessed. Patient's caregiver will be interviewed following the death of the patient to assess clinical symptoms in the last weeks of life and around the time of death.
Methods: Patients will undergo clinical symptom assessment via questionnaire. Patients will be followed by regular semi-structured phone interviews.
Should a patient pass, four weeks following this, the patient's care giver will be interviewed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Tissue proven diagnosis of a high grade brain tumor
- •Disease progression by MRI
- •Therapy resistant tumor to 2nd line chemotherapy
- •Karnofsky Performance Scale (KPS) score of 60 or less
- •Patient will need to assign caregiver
排除标准
- 未提供
结局指标
主要结局
Examination
时间窗: 12 months
Clinical assessment
Quality of life and end of life symptoms in brain tumor patients
时间窗: 12 months
Assessment will be performed with validated questionnaire (MDASI-BT)
次要结局
未报告次要终点
研究者
Tobias Walbert, MD, PhD
Co-Director Hermelin Brain Tumor Center at the Henry Ford Cancer Institute
Henry Ford Health System