Dopaminergic Modulation of Cognition and Psychomotor Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Behavioral score on the Word learning test
研究概览
简要总结
A recent study at our lab showed increased episodic memory consolidation and response readiness after treatment with methylphenidate in healthy volunteers. The investigators seek to replicate and extend these findings. Furthermore the pharmacological specificity of these effects will be studied. Since methylphenidate has an effect on two neurotransmitters, dopamine and noradrenaline, either could be responsible for the observed effects. In order to explore the dopaminergic contribution to this effect, the study proposed here includes not only methylphenidate but also levodopa/carbidopa, which only affects dopamine and not noradrenaline.
In this study, 20 healthy males and females between 18 and 45 years of age will participate. They will be recruited via advertisements at Maastricht University and in local newspapers.
Participants will be treated once with methylphenidate, once with levodopa/carbidopa and once with placebo. All medications will be administered orally with a capsule.
It is hypothesized that methylphenidate and levodopa/carbidopa will both enhance episodic memory consolidation and improve response readiness
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female
- •18 to 45 years of age
- •Healthy (i.e. absence of all exclusion criteria), normal static binocular acuity (corrected or uncorrected),
- •Body mass index between 18.5 and 30
- •Willingness to sign an informed consent.
排除标准
- •history of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological or psychiatric illness.
- •history of depression, bipolar disorder, anxiety disorder, panic disorder, psychosis, or attention deficit hyperactivity disorder will be excluded from participation.
- •first-degree relative with a psychiatric disorder or a history with a psychiatric disorder
- •excessive drinking (>20 glasses of alcohol containing beverages a week
- •pregnancy or lactation
- •use of medication other than oral contraceptives
- •use of recreational drugs from 2 weeks before until the end of the experiment
- •any condition in which gastrointestinal motility might carry any risk
- •any sensory or motor deficits which could reasonably be expected to affect test performance
研究组 & 干预措施
Medication
In this study, a crossover design is applied. All participants receive all three treatments in randomized order on separate days.
干预措施: Methylphenidate 40 mg (Drug)
Medication
In this study, a crossover design is applied. All participants receive all three treatments in randomized order on separate days.
干预措施: Levodopa/carbidopa 125 mg (Drug)
Medication
In this study, a crossover design is applied. All participants receive all three treatments in randomized order on separate days.
干预措施: Domperidon 10 mg (Drug)
结局指标
主要结局
Behavioral score on the Word learning test
时间窗: 1 day
Number of words recalled in the word learning test
次要结局
- CNV amplitude(1 day)
- Reaction time on the CNV(1 day)