Acute Effects of Handgrip on Vascular Function and Ambulatory Blood Pressure in Hypertensive Adults: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 2
- 主要终点
- Change in Ambulatory Blood Pressure
研究概览
简要总结
The effect of handgrip training on blood pressure reduction has been demonstrated in several studies. However, acutely, there is still divergence regarding the effects of isometric handgrip exercise on blood pressure responses, especially when it is performed at different times of the day. It is suggested that the magnitude of blood pressure reduction after a single exercise session is able to predict long-term blood pressure behavior. Thus, understanding the effects of isometric handgrip exercise, performed at different times of the day, on blood pressure in adult hypertensive individuals acutely may help to understand the effects of this type of exercise chronically.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of hypertension controlled by up to three antihypertensive medications;
- •SBP levels ≤ 180 mmHg and/or DBP ≤110 mmHg;
- •no serious heart disease;
- •no upper limb musculoskeletal injury that prevents the handgrip.
排除标准
- •diagnosis of other cardiovascular diseases or diabetes during the study;
- •change the class and/or dose of antihypertensive medication during the study;
- •worsening of the disease (BP > 180 or use of four or more medications).
结局指标
主要结局
Change in Ambulatory Blood Pressure
时间窗: 24 hours after the session
The ambulatory blood pressure will be collected for a 24-hour period using an automatic device (Dyna-MAPA, Cardios, Brazil). The device, duly calibrated, will be connected to a cuff, in the arm of preference, for the evaluation measurements. The device will be programmed to take measurements throughout the day at 15-minute intervals and during the night every 30 minutes (between 11:00 p.m. and 7:00 a.m.). All subjects will be given forms to record possible eventualities during the use of the device.
次要结局
- Change of clinical blood pressure from pre to post session(Before, immediately after, 15 minutes and 30 minutes after the session.)
- Change in vascular function from pre to post session(Before, immediately after and 30 minutes after the session.)
研究者
Aline Mendes Gerage
Professor
Universidade Federal de Santa Catarina