Neural Correlates of Neurofeedback Training
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 210
- 试验地点
- 2
- 主要终点
- brain patterns that mediate learning self-regulation in patients with fMRI neurofeedback
研究概览
简要总结
The objective of the present study is to identify brain networks in patients that contribute to successfully learning self-regulation with real-time fMRI.
详细描述
Neurofeedback has been established as a promising non-pharmacological therapeutic approach. However, patients differ in their ability to learn control over their own brain activity with neurofeedback. It is thus crucial to understand the brain networks that mediate learned self-regulation with real-time fMRI. The objective of the present study is thus to identify brain networks in patients that contribute to successfully learning self-regulation with real-time fMRI. To achieve this goal, patients suffering from depression, post-traumatic stress disorder, and nicotine addiction will be trained to improve their self-regulation skills using established real-time fMRI neurofeedback protocols.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Magnetic resonance imaging compatibility.
- •DSM-V diagnosis of major depressive disorder, post-traumatic stress disorder, or nicotine addiction, respectively.
排除标准
- •Other physical or psychiatric disorders.
- •Current substance abuse.
- •Exclusion criteria applicable to MRI (metallic implants, claustrophobia, epilepsy).
结局指标
主要结局
brain patterns that mediate learning self-regulation in patients with fMRI neurofeedback
时间窗: 12 months
Functional MRI data will be analysed using a whole brain mixed effect analysis across all subjects that compares brain patterns during self-regulation and baseline.
次要结局
- neurofeedback learning success(12 months)
- behavioral consequences of neurofeedback training(12 months)
- maintenance of learned self-regulation(12 months)
研究者
Frank Scharnowski
Prof. Dr.
Psychiatric University Hospital, Zurich