A single-arm exploratory study examining the feasibility of imaging glioblastoma pH using CEST-MRI

niversity of Oxford0 个研究点目标入组 19 人开始时间: 2017年8月7日最近更新: 2021年7月21日

适应症

试验速览

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•1. Participant is willing, capable of cooperating with the protocol and able to give informed consent for participation in the study
•2. Male or female, aged 18 years or above
•3. Diagnosed with glioblastoma and scheduled for neurosurgical resection or debulking

•Current exclusion criteria as of 16/02/2018:
•1. Intolerant of MRI brain (for example: claustrophobia)
•2. MRI brain contraindicated (for example: implanted electric and electronic devices, heart pacemakers, insulin pumps, implanted hearing aids, neurostimulators, intracranial metal clips, metallic bodies in the eye)
•3. Neoadjuvant chemotherapy/radiotherapy treatment for glioblastoma which would interfere with the interpretation of trial results
•4. Pregnancy
•5. Other psychological, social or medical condition that the investigator considers would make the patient a poor trial candidate or could interfere with protocol compliance or the interpretation of trial results
•Previous exclusion criteria:
•1. Intolerant of MRI brain (for example: claustrophobia)
•2. MRI brain contraindicated (for example: implanted electric and electronic devices, heart pacemakers, insulin pumps, implanted hearing aids, neurostimulators, intracranial metal clips, metallic bodies in the eye)
•3. Prior treatment for glioblastoma
•4. Pregnancy
•5. Other psychological, social or medical condition that the investigator considers would make the patient a poor trial candidate or could interfere with protocol compliance or the interpretation of trial results

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