A Prospective Multicentre Cohort Study of Acute ST-segment Elevation Myocardial Infarction
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 2,000
- 试验地点
- 7
- 主要终点
- MACE
研究概览
简要总结
ST-segment elevation myocardial infarction(STEMI) remains a major cause of morbidity and mortality worldwide, despite of the early reperfusion therapy, including fibrinolysis, primary percutaneous coronary intervention (PCI),and standardized medical treatment.To improve the prognosis of STEMI patients, the management in their hospitalization should be optimized, including improvements in risk stratification, more widespread use of an invasive strategy, implementation of care delivery systems prioritising immediate revascularisation through PCI (or fibrinolysis), advances in antiplatelet agents and anticoagulants, and greater use of secondary prevention strategies such as lipid-lowering therapy.
This study aims to standardized the management of STEMI patients and improve the prognosis of the STEMI patients.
详细描述
This study is a prospective cohort study. It aims to standardized the management of STEMI patients and improve the prognosis of the STEMI patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ST elevation myocardial infarction
- •Coronary angiography and percutaneous coronary intervention within 12 hours of symptom onset
- •Capable and willing to provide informed conset and capable of completing study visits
排除标准
- •Cardiovascular shock at admission
- •Severe physical disability
- •Active malignant tumors
- •Active autoimmune diseases
结局指标
主要结局
MACE
时间窗: 0-1 year
Major adverse cardiovascular events(MACE) in one year follow-up
Left Ventricular Function
时间窗: 1 month, 6month and 1 year
Left ventricular end diastolic volume(LVEDV),Left ventricular end systolic volume(LVESE),Left ventricular ejection fraction(LVEF) changes within one year follow-up
Coronary angiography
时间窗: 1 year
The pathological changes in culprit vessels in 1 year
次要结局
未报告次要终点
研究者
RUIYAN ZHANG
Director of Cardiology Department, Chief Physician
Ruijin Hospital