Endovascular Therapy vs Medical Management of PosterIor Cerebral Artery Occlusion Stroke
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,282
- 试验地点
- 22
- 主要终点
- Change in stroke outcome based on modified Rankin Scale (mRS)
研究概览
简要总结
For this retrospective study, the investigators will collect and analyze data of patients who presented with posterior artery occlusion and underwent mechanical thrombectomy (the type of endovascular stroke treatment) and intravenous thrombolysis (the type of non-endovascular stroke treatment).
The electronic health records will be queried for the demographic, medical history, and outcomes data of all patients with posterior cerebral artery occlusion who underwent mechanical thrombectomy, intravenous thrombolysis (IVT), or medical management.
详细描述
The primary aims of the research are to evaluate, in patients presenting with posterior artery occlusion (PCA), whether favorable outcome would be superior for EVT compared to Medically Management (MM), inclusive of intravenous thrombolysis (IVT), as measured by:
- 90-day modified Rankin Scale (mRS) ordinal shift or
- decrease in NIH Stroke Scale/Score (NIHSS) by two points at 24 hours or at hospital discharge
The secondary aims are to evaluate in patients presenting with PCA occlusion, other outcome and safety metrics:
- 90-day functional independence, mRS 0-2
- 90-day excellent outcome, mRS 0-1
- Visual field recovery (none, partial, complete) by 90-days
- rate of reperfusion by modified thrombolysis in cerebral infarction (TICI) scale grade
- any intracranial hemorrhage
- symptomatic intracranial hemorrhage
- mortality
In subgroup analysis, the investigators aim to identify subgroups that may confer differential treatment benefit by:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Had an ischemic stroke with isolated posterior cerebral artery occlusion (P1, P2, or P3 segments) and was medically managed or managed with EVT during the study time period.
排除标准
- •Patient with documented basilar artery occlusion and concomitant PCA occlusion
- •Patient with documented basilar artery occlusion, migration with secondary PCA occlusion
结局指标
主要结局
Change in stroke outcome based on modified Rankin Scale (mRS)
时间窗: baseline, 90 days
The Modified Rankin Scale (mRS) assesses disability in patients who have suffered a stroke and is compared over time to check for recovery and degree of continued disability. Scores can range from 0-6, where 0 is no disability, 5 is disability requiring constant care for all needs, and 6 is death. For this outcome an ordinal shift analysis will be done, assessing all changes across the range from baseline at 90 days.
Change in NIH Stroke Score (NIHSS)
时间窗: baseline, 7 days
The NIH Stroke Scale/Score (NIHSS) is is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. Scores can range from 0 to 42 and higher scores are associated with more severe stroke: 1-4= Minor stroke, 5-15= Moderate stroke, 15-20= Moderate/severe stroke, and 21-42 =Severe stroke.
次要结局
未报告次要终点