ACTRN12621001476820招募中未知
Investigating the effects of L-arginine and aged garlic extract on frequency and severity of migraine in adults
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 入组人数
- 240
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 80 Years（—）
- 性别
- All
入选标准
- •1.Migraine (with or without aura) diagnosed at least 1 year ago
- •2.Migraine onset occurred before 50 years of age
- •3.2-6 migraine episodes and fewer than 6 'other' headache types per month, over the last 3 months
- •4.Able to distinguish between migraine and 'other' headache types
- •5.Able to complete a daily diary about migraine experience
- •6.Able to commit to taking the 5 capsules a day for 14 weeks
排除标准
- •1.Taking medications/drugs affecting vascular tone or blood pressure
- •2.Taking nitrate drugs or isoproterenol (often prescribed for angina or heart failure)
- •3.Taking more than two migraine-prevention drugs
- •4.Taking antidepressants or diuretics, herbs, supplements
- •5. Taking Sildafenil, Cialis, Spedra and any other PGE-5 inhibitor drugs
- •6.Taking drugs with potential blood-vessel effects (analgesics, decongestants, or antihistamines)
- •7.Already taking L-arginine or garlic supplements for 3 months before the study
- •8.Having headaches causing fainting or another medical emergency
- •9.Having chronic daily headaches, medication-overuse headaches and/or other secondary headache disorders
- •10.Having diagnoses other than migraine as the primary cause of headache
- •11.A change in migraine treatment in the 3 months prior to or during the study
- •12.Clinical reports of renal or liver dysfunction
- •13. Clinical risks associated with bleeding or coagulopathy or currently on blood-thinning medications such as warfarin/heparin therapy
- •14.Having any cardiovascular or neoplastic diseases
- •15.Having major chronic metabolic or neurologic disorders, or receiving current therapy for them
- •16.Being diagnosed with psychosis or bipolar affective disorder
- •17.Diagnosis of cancer
- •18.Substance abuse/dependence/addiction in the 3 months prior to or during the study
- •19.Having an history of diabetes, hypertension, collagen vascular disease, vasculitis, or renal disease/failure
- •20.Having any low-blood-pressure-related issues or Type-1 or -2 diabetes
- •21.Having the possibility of pregnancy or lactation
- •22.Being allergic to garlic or its constituents
- •23.Having gastric disturbances such as bloating, stomach pain, heartburn, diarrhoea, constipation, nausea or vomiting
- •24.Are a smoker
- •25.Having an history of eye pathology, surface disorder, surgery (except cataract extraction), injury
- •26.Not being able to see clearly (with glasses, if need be)
- •27.Having disorders of the optic nerve (including glaucoma) or retina
- •28.The significant possibility of our not being able to see the inside of your eye clearly
- •29.Having poor image perception due to cataract or unstable fixation
研究者
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