跳至主要内容
MedPath Trial logoMedPath TrialMedPath Trial Home
临床试验/NCT04742374
NCT04742374已完成早期 1 期

Comparison of the Effects of 2 Therapeutic Plasmapheresis Techniques: Single Plasma Exchange and Double Filtration Plasmapheresis (DFPP) on Peripheral Lymphocyte Phenotypes in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP). A Monocentric Prospective Study With a Single-Case Experimental Design

Centre Hospitalier Universitaire de Nīmes1 个研究点 分布在 1 个国家目标入组 8 人开始时间: 2021年3月12日最近更新:
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit
适应症
干预措施

试验速览

阶段
早期 1 期
状态
已完成
发起方
入组人数
8
试验地点
1
主要终点
Cycle 2, Group A: TH1 cells BEFORE double filtration plasmapheresis
研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

CIDP, a rare disorder affecting young adults, causes gradual weakness of the limbs, areflexia and impaired sensory function. New CIDP phenotypes without antibodies but with modified cell profiles have been described. Treatments include corticotherapy, IVIg and plasmapheresis but the latter's action mechanisms remain unclear. Plasmapheresis supposedly removes toxic agents like antibodies from plasma but it is uncertain whether it has an immune-modulating effect. Also, the refining mechanisms of the two main plasmapheresis techniques - single plasma exchange and double filtration plasmapheresis (DFPP) - are different and unclear. This study aims to compare the evolution of peripheral lymphocyte profiles in patients with CIDP according to their treatment (single centrifugation plasmapheresis or DFPP) to better grasp the action mechanisms of both techniques.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Treatment
盲法
Single (Participant)

盲法说明

Randomisation to one of two treatments before alternation.

入排标准

年龄范围
18 Years 至 —（Adult, Older Adult）
性别
All
接受健康志愿者
否

入选标准

  • •Patients with confirmed Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) without pathogenic antibodies and stable under therapeutic plasmapheresis with one session every 2-3 weeks for at least two months.
  • •Patients who have given free written informed consent.
  • •Patients who have signed the consent form.
  • •Patients affiliated to or beneficiaries of a health insurance scheme.
  • •Adult patients (≥18 ans).
  • •Healthy subjects of the same age and sex

排除标准

  • •Patients Under the age of
  • •Patients under immunosuppressive treatment for less than 3 months.
  • •Patients participating in Category 1 research involving human subjects.
  • •Patients in an exclusion period determined by another study.
  • •Patients under legal protection, guardianship or curatorship.
  • •Patients unable to express consent.
  • •Patients for whom it is impossible to give informed information.
  • •Pregnant, parturient or breastfeeding patients.
  • •Healthy subject with chronic pathology or drug treatment

研究组 & 干预措施

Group A

Experimental

Patients alternating single plasma exchange followed by double filtration plasmapheresis etc.

干预措施: Blood sampling (Biological)

Group B

Experimental

Patients alternating double filtration plasmapheresis followed by single plasma exchange etc.

干预措施: Blood sampling (Biological)

结局指标

主要结局

Cycle 2, Group A: TH1 cells BEFORE double filtration plasmapheresis

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 cells will be measured in %.

Cycle 2, Group A: TH1 cells AFTER double filtration plasmapheresis

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 cells will be measured in %.

Cycle 2, Group A: TH1 cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7 - 10

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 cells will be measured in %.

Cycle 1, Group A : T-reg cells BEFORE first single plasma exchange

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 1, Group B : T17 cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 1, Group B : T-reg cells BEFORE double filtration plasmapheresis

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 2, Group A: TH17 cells AFTER double filtration plasmapheresis

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 2, Group A: TH17 cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 2, Group B: TH17 cells 7-10 days AFTER single plasma exchange

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

Cycle 1, Group A : TH1 cells 7-10 days AFTER single plasma exchange

时间窗: Day 7 -10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 1, Group A : TH17 cells 7 - 10 days AFTER single plasma exchange

时间窗: Day 7 - 10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 peripheral lymphocyte cells will be measured in %.

Cycle 1, Group B : T-reg cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7 - 10

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 2, Group A: T-reg cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 2, Group B: TH1 cells 7-10 days AFTER single plasma exchange

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 cells will be measured in %.

Cycle 3, Group A: TH17 cells AFTER single plasma exchange

时间窗: Day 1, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

Cycle 1, Group A : T-reg cells AFTER single plasma exchange

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 1, Group B : T-reg cells AFTER double filtration plasmapheresis

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 2, Group A: TH17 cells BEFORE double filtration plasmapheresis

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 2, Group A: T-reg cells BEFORE double filtration plasmapheresis

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 3, Group A: TH1 cells AFTER single plasma exchange

时间窗: Day 1, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 1, Group A : TH1 cells BEFORE single plasma exchange

时间窗: Day 0, Time 0

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 1, Group B : TH1 cells BEFORE first double filtration plasmapheresis

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 1, Group B : TH1 cells 7-10 days AFTER the first double filtration plasmapheresis

时间窗: Day 7 - 10

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 1, Group B : TH17 cells BEFORE the first double filtration plasmapheresis

时间窗: Day0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 1, Group A : TH1 cells AFTER single plasma exchange

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 1, Group A : TH17 cells BEFORE first single plasma exchange

时间窗: Day 0, Time 0

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 peripheral lymphocyte cells will be measured in %.

Cycle 1, Group A : TH17 cells AFTER single plasma exchange

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 peripheral lymphocyte cells will be measured in %.

Cycle 1, Group A : T-reg cells 7 - 10 days AFTER single plasma exchange

时间窗: Day 7 - 10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 1, Group B : TH1 cells AFTER the first double filtration plasmapheresis

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 1, Group B : TH17 cells AFTER the first double filtration plasmapheresis

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 2, Group B: TH1 cells BEFORE single plasma exchange

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 cells will be measured in %.

Cycle 2, Group B: TH1 cells AFTER single plasma exchange

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 cells will be measured in %.

Cycle 3, Group A: T1 cells 7-10 days AFTER single plasma exchange

时间窗: Day 7 - 10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 6, Group A : TH17 cells BEFORE double filtration plasmapheresis

时间窗: Day 0 Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 2, Group A: T-reg cells AFTER double filtration plasmapheresis

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 2, Group B: T17 cells BEFORE single plasma exchange

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T17 cells will be measured in %.

Cycle 2, Group B: TH17 cells AFTER single plasma exchange

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T17 cells will be measured in %.

Cycle 2, Group B: T-reg cells BEFORE single plasma exchange

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 2, Group B: T-reg cells AFTER single plasma exchange

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 3, Group A: T-reg cells 7-10 days AFTER single plasma exchange

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 3, Group B: TH1 cells BEFORE double filtration plasmapheresis

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 3, Group B: TH1 cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 4, Group A: TH17 cells AFTER double filtration plasmapheresis

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 4, Group A: T-reg cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7 - 10

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg peripheral lymphocyte cells will be measured in %.

Cycle 4, Group B : TH1 cells BEFORE single plasma exchange

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 3, Group B: T-reg cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 2, Group B: T-reg cells 7-10 days AFTER single plasma exchange

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 3, Group A: TH1 cells BEFORE single plasma exchange

时间窗: Day 1, Hour 1

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 4, Group A: T1 cells AFTER double filtration plasmapheresis

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T1 peripheral lymphocyte cells will be measured in %.

Cycle 4, Group B : T17 cells 7-10 days AFTER single plasma exchange

时间窗: Day 7 -10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T1 peripheral lymphocyte cells will be measured in %.

Cycle 5, Group A : TH17 cells AFTER single plasma exchange

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

Cycle 5, Group B : TH1 cells AFTER double filtration plasmapheresis

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 5, Group B : TH17 cells BEFORE double filtration plasmapheresis

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 5, Group B : TH17 cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 3, Group A: T-reg cells BEFORE single plasma exchange

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 3, Group B: TH17 cells BEFORE double filtration plasmapheresis

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 4, Group A: TH1 cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7 - 10

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 4, Group A: TH17 cells BEFORE double filtration plasmapheresis

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 5, Group A : TH17 cells BEFORE single plasma exchange

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.

Cycle 5, Group A : T-reg cells AFTER single plasma exchange

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 5, Group B : TH1 cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 3, Group A: TH17 cells BEFORE single plasma exchange

时间窗: Day 1, Hour 1

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.

Cycle 3, Group A: T-reg cells AFTER single plasma exchange

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 3, Group B: TH1 cells AFTER double filtration plasmapheresis

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 3, Group B: TH17 cells AFTER double filtration plasmapheresis

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 4, Group A: T-reg cells BEFORE double filtration plasmapheresis

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 4, Group A: T-reg cells AFTER double filtration plasmapheresis

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 4, Group B : T-reg cells BEFORE single plasma exchange

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 5, Group A : TH1 cells BEFORE single plasma exchange

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 6, Group A : TH1 cells BEFORE double filtration plasmapheresis

时间窗: Day 0 Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 3, Group A: TH17 cells 7-10 days AFTER single plasma exchange

时间窗: Day 7 - 10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

Cycle 3, Group B: TH17 cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 3, Group B: T-reg cells BEFORE double filtration plasmapheresis

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 3, Group B: T-reg cells AFTER double filtration plasmapheresis

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 4, Group A: T1 cells BEFORE double filtration plasmapheresis

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T1 peripheral lymphocyte cells will be measured in %.

Cycle 4, Group A: TH17 cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7 - 10

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 peripheral lymphocyte cells will be measured in %.

Cycle 4, Group B : TH17 cells AFTER single plasma exchange

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

Cycle 4, Group B : T-reg cells 7-10 days AFTER single plasma exchange

时间窗: Day 7 - 10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 5, Group A : TH17 cells 7-10 days AFTER single plasma exchange

时间窗: Day 7 - 10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

Cycle 5, Group B : TH1 cells BEFORE double filtration plasmapheresis

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 5, Group B : TH17 cells AFTER double filtration plasmapheresis

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 4, Group B : TH1 cells AFTER single plasma exchange

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 4, Group B : TH1 cells 7-10 days AFTER single plasma exchange

时间窗: Day 7 -10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 4, Group B : TH17 cells BEFORE single plasma exchange

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.

Cycle 4, Group B : T-reg cells AFTER single plasma exchange

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 5, Group A : TH1 cells AFTER single plasma exchange

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 5, Group A : TH1 cells 7-10 days AFTER single plasma exchange

时间窗: Day 7 - 10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 cells will be measured in %.

Cycle 5, Group A : T-reg cells BEFORE single plasma exchange

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 5, Group A : T-reg cells 7-10 days AFTER single plasma exchange

时间窗: Day 7 - 10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 6, Group A : TH1 cells AFTER double filtration plasmapheresis

时间窗: Day 0 Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 6, Group B : TH17 cells AFTER single plasma exchange

时间窗: Day 0 Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

Cycle 6, Group A : TH1 cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 5, Group B : T-reg cells BEFORE double filtration plasmapheresis

时间窗: Day 0, Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 5, Group B : T-reg cells AFTER double filtration plasmapheresis

时间窗: Day 0, Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 5, Group B : T-reg cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 6, Group A : TH17 cells AFTER double filtration plasmapheresis

时间窗: Day 0 Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 6, Group A : T-reg cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 6, Group B : TH1 cells AFTER single plasma exchange

时间窗: Day 0 Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 6, Group B : T-reg cells 7-10 days AFTER single plasma exchange

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 6, Group A : TH17 cells 7-10 days AFTER double filtration plasmapheresis

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

Cycle 6, Group B : TH1 cells BEFORE single plasma exchange

时间窗: Day 0 Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 6, Group B : TH1 cells 7-10 days AFTER single plasma exchange

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

Cycle 6, Group B : T-reg cells BEFORE single plasma exchange

时间窗: Day 0 Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

Cycle 6, Group A : T-reg cells BEFORE double filtration plasmapheresis

时间窗: Day 0 Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 6, Group A : T-reg cells AFTER double filtration plasmapheresis

时间窗: Day 0 Hour 3

5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

Cycle 6, Group B : TH17 cells BEFORE single plasma exchange

时间窗: Day 0 Hour 0

5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.

Cycle 6, Group B : TH17 cells 7-10 days AFTER single plasma exchange

时间窗: Day 7-10

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

Cycle 6, Group B : T-reg cells AFTER single plasma exchange

时间窗: Day 0 Hour 3

5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

次要结局

  • Cycle 1, Group B: CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 1, Group A : T4 lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 1, Group A : T4-DR+ lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 1, Group B: T8 DR+ lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 1, Group A : T4 lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 1, Group B:T4 DR+ lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 1, Group B:T8 lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 1, Group B: CCR6-CXCR3- cells AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 1, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 1, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 1, Group A : T8 lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 1, Group A : T8 DR+ lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 1, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 1, Group A : CR6-CXCR3- cells AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 1, Group B: B lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 1, Group B: CD45RA-CCR7- cells BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 1, Group B:T8 DR+ lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 1, Group B: CD45RA-CCR7- cells AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 1, Group A : T8 lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 1, Group A : B lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 1, Group A : CD45RA-CCR7+ cells BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 1, Group A : T4-DR+ lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 1, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 1, Group A : B lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 1, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 1, Group A : CD45RA+CCR7+ cells BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 1, Group A : CD45RA-CCR7- cells BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 1, Group A : B lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 1, Group A : CD45RA-CCR7- cells AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 1, Group A : T4 lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 1, Group A : T4-DR+ lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 1, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 1, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 1, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 1, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 1, Group B: T4 DR+ lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 1, Group B: CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 1, Group B: CCR6-CXCR3- cells BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 1, Group B:T4 lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 1, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 1, Group B: T4 lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 1, Group B: T8 lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 1, Group B: CD45RA+CCR7+ cells AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 1, Group B: B lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 2, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 2, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 2, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 1, Group B: B lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 1, Group B: CD45RA-CCR7+ cells AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 1, Group B: CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 1, Group B: CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 2, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 2, Group A : B lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 2, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 2, Group A : T8 lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 2, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 2, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 1, Group B: T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 1, Group B: T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 1, Group B: T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 1, Group B: CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 2, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 2, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 2, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 2, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7 - 10)
  • Cycle 1, Group B: T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 1, Group B: CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 2, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 2, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 2, Group A : T4 lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 2, Group A : B lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 2, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7 - 10)
  • Cycle 2, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis(Day 7 - 10)
  • Cycle 2, Group B : T8 lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 2, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 2, Group B : T4 lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 2, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 2, Group B : T4 DR+ lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 2, Group B : B lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 3, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 2, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 2, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7 - 10)
  • Cycle 2, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis(Day 7 - 10)
  • Cycle 2, Group B : B lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 2, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 2, Group B : B lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 2, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 3, Group A : T8 lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 2, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7 - 10)
  • Cycle 2, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis(Day 7 - 10)
  • Cycle 2, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis(Day 7 - 10)
  • Cycle 2, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 2, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 2, Group B : T4 DR+ lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 2, Group B : CD45RA-CCR7- cells AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 2, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7 - 10)
  • Cycle 2, Group B : T4 lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 2, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 2, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 2, Group B : CCR6-CXCR3- cells AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 2, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 2, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 3, Group A : T8 lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 3, Group A : B lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 2, Group B : T8 lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 2, Group B : T8 DR+ lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 2, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 2, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 2, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 2, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 3, Group A : T4 DR+ lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 3, Group A : CC45RA-CCR7+ cells BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 3, Group A : T4 lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 3, Group A : T4 DR+ lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 2, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 2, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 3, Group A : T4 lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 3, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 3, Group A : CC45RA-CCR7- cells BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 3, Group A : T8 DR+ lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 3, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 3, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 3, Group A : CC45RA+CCR7+ cells BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 3, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 3, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 3, Group A : B lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 3, Group B : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 3, Group B : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 3, Group B : T4 lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 3, Group A : B lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 3, Group A : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 3, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 3, Group B : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 3, Group B : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 3, Group B : T8 DR+ lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 3, Group B : CD45RA-CCR7- cells AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 3, Group A : CD45RA-CCR7- cells AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 3, Group A : CCR6-CXCR3- cells AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 3, Group A : T4 lymphocytes 7 -10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 3, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 3, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 3, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 3, Group B : T4 lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 3, Group B : T8 lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 3, Group B : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 3, Group B : B lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 3, Group B : T4 DR+ lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 3, Group B : T8 lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 3, Group B : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 4, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 4, Group A : B lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 3, Group B : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 3, Group B : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 3, Group B : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 4, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 4, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 4, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 4, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 3, Group B : B lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 3, Group B : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 3, Group B : B lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 3, Group B : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 4, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 4, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 3, Group B : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 3, Group B : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 3, Group B : CCR6-CXCR3- cells AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 3, Group B : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 3, Group B : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 4, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 4, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 4, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 3, Group B : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 4, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 4, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis(Day 0 Hour 0)
  • Cycle 4, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 4, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 4, Group A : T4 lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 4, Group A : T8 lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 4, Group A : B lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 4, Group B : T4 lymphocytes BEFORE plasma exchange(Day 0 Hour 0)
  • Cycle 4, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 4, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 4, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 4, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 4, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis(Day 0 Hour 3)
  • Cycle 4, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 4, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 4, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 5, Group A : T4 lymphocytes BEFORE single plasma exchange(Day 0, Hour 0)
  • Cycle 5, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange(Day 0, Hour 0)
  • Cycle 5, Group B : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 4, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 4, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 4, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 4, Group B : T8 lymphocytes BEFORE plasma exchange(Day 0 Hour 0)
  • Cycle 4, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 4, Group B : T4 lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 4, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 5, Group A : CD45RA-CCR7- cells BEFORE single plasma exchange(Day 0, Hour 0)
  • Cycle 5, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange(Day 0, Hour 0)
  • Cycle 4, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 4, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 4, Group B : T8 DR+ lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 4, Group B : CD45RA-CCR7- cells AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 5, Group A : T8 lymphocytes BEFORE single plasma exchange(Day 0, Hour 0)
  • Cycle 5, Group A : B lymphocytes BEFORE single plasma exchange(Day 0, Hour 0)
  • Cycle 5, Group A : CD45RA-CCR7+ cells BEFORE single plasma exchange(Day 0, Hour 0)
  • Cycle 5, Group A : B lymphocytes AFTER single plasma exchange(Day 0, Hour 3)
  • Cycle 4, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 4, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 4, Group B : T4 DR+ lymphocytes BEFORE plasma exchange(Day 0 Hour 0)
  • Cycle 4, Group B : B lymphocytes BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 4, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange(Day 0 Hour 0)
  • Cycle 4, Group B : T8 lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 4, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 4, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 4, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 5, Group A : T4 DR+ lymphocytes BEFORE single plasma exchange(Day 0, Hour 0)
  • Cycle 5, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange(Day 0, Hour 3)
  • Cycle 4, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 4, Group B : T4 DR+ lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 4, Group B : B lymphocytes AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 4, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 4, Group B : CCR6-CXCR3- cells AFTER single plasma exchange(Day 0 Hour 3)
  • Cycle 4, Group B : B lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 4, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 5, Group A : CD45RA+CCR7+ cells BEFORE single plasma exchange(Day 0, Hour 0)
  • Cycle 5, Group A : T4 lymphocytes AFTER single plasma exchange(Day 0, Hour 3)
  • Cycle 5, Group A : T4 DR+ lymphocytes AFTER single plasma exchange(Day 0, Hour 3)
  • Cycle 5, Group A : T8 lymphocytes AFTER single plasma exchange(Day 0, Hour 3)
  • Cycle 5, Group A : B lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 5, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 5, Group B : B lymphocytes BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 5, Group B : T4 DR+ lymphocytes AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 5, Group B : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 6, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 5, Group A : T8 DR+ lymphocytes AFTER single plasma exchange(Day 0, Hour 3)
  • Cycle 5, Group A : T4 lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 5, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 5, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 5, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 5, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 5, Group B : T4 lymphocytes BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 5, Group B : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 5, Group B : T4 lymphocytes AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 5, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange(Day 0, Hour 3)
  • Cycle 5, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 5, Group B : T8 lymphocytes BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 5, Group B : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 5, Group B : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 5, Group B : T8 lymphocytes AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 6, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 6, Group A : B lymphocytes AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 6, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 6, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange(Day 0, H0)
  • Cycle 6, Group B : CD45RA-CCR7- cells AFTER single plasma exchange(Day 0, H3)
  • Cycle 5, Group A : CD45RA-CCR7- cells AFTER single plasma exchange(Day 0, Hour 3)
  • Cycle 5, Group A : CCR6-CXCR3- cells AFTER single plasma exchange(Day 0, Hour 3)
  • Cycle 5, Group A : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 5, Group B : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 5, Group B : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 5, Group B : T8 DR+ lymphocytes AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 5, Group B : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 5, Group B : B lymphocytes AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 5, Group B : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 5, Group B : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 6, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 6, Group B : T8 lymphocytes BEFORE single plasma exchange(Day 0, H0)
  • Cycle 6, Group B : T4 DR+ lymphocytes AFTER single plasma exchange(Day 0, H3)
  • Cycle 6, Group B : B lymphocytes AFTER single plasma exchange(Day 0, H3)
  • Cycle 6, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange(Day 0, H3)
  • Cycle 6, Group B : CCR6-CXCR3- cells AFTER single plasma exchange(Day 0, H3)
  • Cycle 5, Group B : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 5, Group B : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 5, Group B : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 5, Group B : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 5, Group B : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 6, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 6, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 6, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 6, Group B : B lymphocytes BEFORE single plasma exchange(Day 0, H0)
  • Cycle 6, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange(Day 0, H0)
  • Cycle 5, Group B : CD45RA-CCR7- cells AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 5, Group B : CCR6-CXCR3- cells AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 5, Group B : B lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 5, Group B : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 6, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 6, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 6, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 6, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 6, Group A : B lymphocytes BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 6, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis(Day 0, Hour 0)
  • Cycle 6, Group A : T4 lymphocytes AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 6, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 6, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 6, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 6, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 6, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange(Day 0, H0)
  • Cycle 6, Group B : B lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 6, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 6, Group A : T8 lymphocytes AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 6, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis(Day 0, Hour 3)
  • Cycle 6, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 6, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 6, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 6, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 6, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 6, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis(Day 7-10)
  • Cycle 6, Group B : T4 lymphocytes BEFORE single plasma exchange(Day 0, H0)
  • Cycle 6, Group B : T4 DR+ lymphocytes BEFORE single plasma exchange(Day 0, H0)
  • Cycle 6, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange(Day 0, H0)
  • Cycle 6, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange(Day 0, H0)
  • Cycle 6, Group B : T4 lymphocytes AFTER single plasma exchange(Day 0, H3)
  • Cycle 6, Group B : T8 lymphocytes AFTER single plasma exchange(Day 0, H3)
  • Cycle 6, Group B : T8 DR+ lymphocytes AFTER single plasma exchange(Day 0, H3)
  • Cycle 6, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange(Day 0, H3)
  • Cycle 6, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 6, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 6, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 6, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 6, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 6, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange(Day 7-10)
  • Cycle 6, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange(Day 7-10)

研究者

发起方
Centre Hospitalier Universitaire de Nīmes
申办方类型
Other
责任方
Sponsor

研究点 (1)

Loading locations...

相似试验

已完成
1 期
Physical, Functional and Neural Effects of Two Lower Extremity Exercise Protocols in Children With Cerebral PalsyChildrenAdolescentsCerebral Palsy
NCT01086670National Institutes of Health Clinical Center (CC)55
已完成
不适用
Lower Extremity Evaluation in Children With Diparetic Cerebral Palsy According to ICF PerspectiveDiparesisDiplegic Cerebral PalsyLower Extremity ParesisCerebral Palsy
NCT06583746Acıbadem Atunizade Hospital30
已完成
3 期
Dupilumab for the Treatment of Chronic Inducible Cold Urticaria in Patients Who Remain Symptomatic Despite the Use of H1-antihistamine (LIBERTY-CINDU CUrIADS)Cold Urticaria
NCT04681729Sanofi82
终止
不适用
PROMs and Patellar Tracking After MPFL Reconstruction With or Without Tibial Tuberosity TranspositionPatellar DislocationPatellar Dislocation, RecurrentPatellofemoral Maltracking
NCT05547269Radboud University Medical Center11
已完成
1 期
Congenital Muscular Dystrophy Ascending Multiple Dose Cohort Study Analyzing Pharmacokinetics at Three Dose Levels In Children and Adolescents With Assessment of Safety and Tolerability of Omigapil (CALLISTO)Congenital Muscular Dystrophy
NCT01805024Santhera Pharmaceuticals20