Using High-resolution Electroencephalography to Optimize the Evaluation of Awareness in Patients With Disorders of Consciousness
试验速览
- 阶段
- 不适用
- 入组人数
- 28
- 主要终点
- Number of participants showing differences of electrophysiological activity after personalized but not standard stimulation protocols
研究概览
简要总结
The purpose of this study is to evaluate whether personalized stimulations can improve the detection of electrophysiological signs of awareness in patients with disorders of consciousness.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients in a vegetative state or a minimally conscious state
- •agreement from families
排除标准
- •patients with akinetic mutism or locked-in syndrome
- •patients in a coma
- •patients with damages in the inner or middle ear
- •contraindication to a high-density electroencephalography exam
研究组 & 干预措施
electroencephalography recording
Cerebral measurements from high-density electroencephalography after the presentation of personalized stimulations
干预措施: high-density electroencephalography (Device)
结局指标
主要结局
Number of participants showing differences of electrophysiological activity after personalized but not standard stimulation protocols
时间窗: standard stimulations: 28 days after recruiting patients
Depending of the personalized stimulation protocol, the differences of electrophysiological activity can the presence of event-related potentials (N100, mismatch negativity, P300, etc.) or alterations of neural oscillations. The personalized stimulation protocol will be chosen according to the families' feeling of a presence.
次要结局
未报告次要终点