Sleep Apnea and High Altitude Pulmonary Hypertension in Kyrgyz Highlanders
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 125
- 试验地点
- 1
- 主要终点
- Sleep related breathing disturbances
研究概览
简要总结
High altitude pulmonary hypertension, a form of altitude illness that occurs in long-term residents at altitudes >2500 m, is characterized by dyspnea, hypoxemia, impaired exercise performance and hypertension in the pulmonary circulation. Whether sleep related breathing disturbances, common causes of nocturnal hypoxemia in lowlanders, are also prevalent in highlanders and promote pulmonary hypertension in highlanders is unknown. Therefore, the current study will investigate whether highlanders with high altitude pulmonary hypertension have a greater prevalence of sleep apnea than healthy highlanders and lowlanders.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •high altitude pulmonary hypertension confirmed by clinical presentation and systolic pulmonary artery pressure >50 mmHg measured by echocardiography at altitude of residence.
- •healthy subjects (high altitude controls)
- •Both genders
- •Age >16 y
- •Kyrgyz ethnicity
- •born, raised and currently living at >2500 m
- •healthy subjects currently living at <1000 m (low altitude controls)
- •Exclusion criteria:
- •Pulmonary hypertension from other causes, in particular from left ventricular failure as judged clinically and by echocardiography
- •excessive erythrocytosis
- •other coexistent disorders that may interfere with the cardio-respiratory system and sleep
- •regular use of medication that affects control of breathing
- •heavy smoking
排除标准
- 未提供
结局指标
主要结局
Sleep related breathing disturbances
时间窗: 4 months
Nocturnal oxygen saturation and apnea/hypopnea index
次要结局
- Disease specific quality of life(4 months)
- Subjective sleepiness(4 months)
- Pulmonary artery pressure(4 months)
- Dyspnea(4 months)
- Vigilance(4 months)
- Exercise performance(4 months)
- Pulmonary function(4 months)
- Cerebral oxygen saturation(4 months)
- Mountain sickness(4 months)
- Generic quality of life(4 months)
研究者
Konrad E. Bloch
Professor
University of Zurich