What is the Optimal Cycle Regimen for Frozen- Thawed Embryo Transfer Cycles: Spontaneous Natural Cycles Versus Hormonal Replacement Treatment (HRT) Cycles
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 4
- 试验地点
- 1
- 主要终点
- Ongoing pregnancy rate to 8 weeks gestation
研究概览
简要总结
Investigators will be comparing artificial (HRT) frozen-thawed embryo transfer cycles to correctly conducted spontaneous natural cycles after the transfer of a chromosomally normal embryo.
详细描述
The most common treatment protocols for frozen embryo transfers include natural cycles with or without human chorionic gonadotrophin (HCG) trigger or endometrial preparation with hormonal treatment (artificial cycles), with or without Gonadotrophin - releasing hormone agonist suppression. Recent studies comparing artificial and natural cycles concluded that the optimal means of endometrial preparation for frozen- thawed cycle remains unclear and both options may be offered to women with regular ovulatory cycles.
Correctly identified spontaneous natural cycles are the preferred option for frozen-thawed embryo transfer in women with regular menstrual cycles.
Investigators will be comparing artificial (HRT) frozen-thawed embryo transfer cycles to correctly conducted spontaneous natural cycles after the transfer of a chromosomally normal embryo.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 42 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Ongoing pregnancy rate to 8 weeks gestation
时间窗: 8 weeks
viable pregnancy to 8 gestational weeks
Biochemical pregnancy rate
时间窗: 5 weeks
Positive ß-hCG, but at 5 gestational weeks no ultrasonographic visible gestational sac seen
Clinical implantation rate
时间窗: 6 weeks
Number of gestational sacs observed by ultrasound at 6 weeks of gestation divided by the number of embryos transferred
Clinical pregnancy rate
时间窗: 5 weeks
Ultrasonographic visible sac at 5 gestational weeks
Pregnancy rate beta human chorionic gonadotropin (ß-hCG) > 5 IU
时间窗: 12 days
Number of patients with a hCG \> 5 IU out of the number of patients who underwent an embryo transfer with one or two euploid embryos
次要结局
未报告次要终点
研究者
Prof Dr. Human Fatemi
Medical Director
ART Fertility Clinics LLC