Spectral Analyses of Resting Postural Tremor Measured by Accelerometer and Gyroscope as a Predictive Tool of Multiple Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
- 试验地点
- 3
- 主要终点
- Tremor
研究概览
简要总结
Early diagnosis is a key factor for effective treatment of multiple sclerosis. Accelerometer and gyroscope measurement of tremor could screen potential motor control dysfunction and predict a risk for development of multiple sclerosis.
详细描述
The aim of this study is to test whether specially developed accelerometer and gyroscope can differentiate pattern of resting postural tremor in healthy and people with multiple sclerosis.
Spectral analysis and the correlation of the average signal spectra will be computed. Moreover, categorization based on the tremor component according to the maximum likelihood estimation will be done.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Definite diagnosis of MS
- •prevailed motor deficit of upper extremities, but without visible tremor
- •stable clinical status in the preceding 3 months
- •Expanded Disability Status Scale score (EDSS) ≥ 2 ≤ 7.5, and
- •no corticosteroid therapy in the preceding month
- •Healthy volunteers in the age of 20-70 years will be employed
- •There will be defined as persons without any neurological disease diagnose at the time of the measurement.
- •Exclusion Criteria (both groups):
- •Patients with factors disturbing mobility (e.g. stroke, pregnancy, fractures) were excluded from the study.
排除标准
- 未提供
结局指标
主要结局
Tremor
时间窗: baseline
accelerometer (1 m·s-2)
次要结局
- Psychomotor processing speed(baseline)
- Hand grip strength(baseline)
- Hand and arm function(baseline)
研究者
Kamila Řasová
associate professor PhDr. Kamila Řasová, Ph.D.
Charles University, Czech Republic