Thoracic Fluid Content by Electrical Cardiometry Versus Lung Ultrasound Score as Predictors of Weaning Outcome in Mechanically Ventilated Intensive Care Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 85
- 试验地点
- 1
- 主要终点
- Comparing the area under the curve (AUC) of receiver operating characteristic (ROC) for thoracic fluid content (TFC) and lung ultrasound score.
研究概览
简要总结
This study aims to compare the accuracy of the total thoracic fluid content (TFC) measured by electrical cardiometry with accuracy of lung ultrasound score in prediction of weaning outcome in mechanically ventilated patients.
详细描述
Weaning of patients from mechanical ventilation remains one of the critical decisions in the intensive care unit. Earlier patient weaning from mechanical ventilation is recommended to avoid complications of prolonged mechanical ventilation; however, premature weaning might result in extubation failure which is, independently, associated with poor outcomes.
Screening for eligibility is the first step in the weaning process, followed by the spontaneous breathing trial (SBT). Various indices should be checked carefully before starting a spontaneous breathing trial to ensure adequate oxygenation, ventilation, and airway reflexes. However, nearly one-third of patients fail and are reintubated despite fulfillment of all the current weaning pre-requisites.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •85 mechanically ventilated patients for ≥ 48 hours
- •Aged 18-65 years
- •Fulfilled the weaning readiness criteria
- •Scheduled for spontaneous breathing trial (SBT) using pressure support ventilation.
排除标准
- •Acute respiratory distress syndrome (ARDS) patients.
- •Interstitial lung fibrosis.
- •Patients with lung resection.
- •Pulmonary embolism.
- •Patients with fluid overload due to heart, renal or hepatic failure.
- •Cardiac patients with ejection fraction less than 40%, cardiomyopathy, congenital or valvular heart diseases.
- •Pneumothorax.
- •Pleural or pericardial effusion.
- •Pregnancy.
- •Patients with injuries, burns, or wounds which precluded the proper application of the device electrodes or the ultrasound transducer.
结局指标
主要结局
Comparing the area under the curve (AUC) of receiver operating characteristic (ROC) for thoracic fluid content (TFC) and lung ultrasound score.
时间窗: Two days after the extubation
Comparing the area under the curve (AUC) of receiver operating characteristic (ROC) for thoracic fluid content (TFC) and lung ultrasound score (minimum score, normal lungs: 0; maximum score, both consolidated lungs: 36) in prediction of weaning outcome in mechanically ventilated patients.
次要结局
- The degree of lung compliance(Before initiation of spontaneous breathing trial and before extubation.)
- Prediction of weaning through rapid shallow breathing index (RSBI)(Two days after the extubation)
- Cumulative fluid balance(within 24 hours of spontaneous breathing trial)
研究者
Esraa Rabie Amer
Assistant lecturer of Anesthesiology, Surgical Intensive Care and Pain Management
Tanta University