Transdiagnostic Cognitive Biomarkers
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Feasibility for all aspects of the study
研究概览
简要总结
The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depression as well as healthy controls.
详细描述
This study aims to test the feasibility of procedures aimed at discovering transdiagnostic biomarkers for cognitive impairment in chronic pain and depression. Fifteen healthy control participants and 15 participants from each disease group (chronic pain, depression) will be recruited.
Using a task-based fmri, TMS will be targeted for priming of the Left DLPFC. EEG will be used during our behavioral paradigm to compare changes in DLPFC function before and after primed TMS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Arm 1, healthy controls:
- •Inclusion Criteria:
- •Have access to the online study platform.
排除标准
- •under 18, non-English speaking
- •Arm 2: pain and depression:
- •Inclusion Criteria:
- •Pain or depression
- •Exclusion Criteria:
- •pregnant women
研究组 & 干预措施
Healthy Comparison Group
Behavioral tasks and surveys online.
干预措施: Computer game/task (Behavioral)
Pain/Depression patients from clinic
MRI, TMS and EEG, and behavioral tasks and surveys online.
干预措施: Computer game/task (Behavioral)
Pain/Depression patients from clinic
MRI, TMS and EEG, and behavioral tasks and surveys online.
干预措施: Health surveys online (Behavioral)
Healthy Comparison Group
Behavioral tasks and surveys online.
干预措施: Health surveys online (Behavioral)
结局指标
主要结局
Feasibility for all aspects of the study
时间窗: 1-7 days
Feasibility; the overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depression as well as healthy controls.
次要结局
- Acceptability(1-7 days)